CAS · 636-95-3
Product Overview
3-Nitrophenylhydrazine hydrochloride is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | yellow powder |
|---|---|
| Assay (HPLC): | 98% min |
| Water content: | 1.0% max |
Applications
1. Analytical Chemistry
Derivatization Reagent:
Commonly used as a reagent to derivatize aldehydes and ketones into hydrazones. This improves the detectability and stability of carbonyl compounds in chromatographic and spectroscopic analysis.
HPLC/GC Analysis:
Forms hydrazone derivatives that can be analyzed by High Performance Liquid Chromatography (HPLC) or Gas Chromatography (GC), enhancing sensitivity and selectivity.
2. Organic Synthesis
Intermediate for Hydrazone Formation:
Used in the synthesis of various heterocyclic compounds and azo dyes through condensation reactions with carbonyl compounds.
Precursor in Medicinal Chemistry:
Hydrazones derived from 3-nitrophenylhydrazine are explored for biological activities, including antimicrobial, anticancer, and anti-inflammatory properties.
3. Pharmaceutical Industry
Utilized in the synthesis of drug intermediates involving hydrazine chemistry.
Benefits
Enhanced Reactivity:
The nitro group increases electrophilicity of the hydrazine nitrogen, facilitating rapid and efficient hydrazone formation.
Improved Analytical Sensitivity:
Derivatives formed have better chromatographic behavior, improving detection limits in trace analysis.
Versatility:
Suitable for a broad range of carbonyl compounds, including aliphatic and aromatic aldehydes/ketones.
Conclusion
3-Nitrophenylhydrazine Hydrochloride (CAS 636-95-3) is a valuable reagent in analytical chemistry and organic synthesis. Its ability to form stable hydrazone derivatives with carbonyl compounds makes it essential for chromatographic analysis and as an intermediate in heterocyclic and pharmaceutical chemistry. Its high reactivity, combined with the ease of handling in hydrochloride form, supports its broad application across research and industry.
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