2-Chloro-5-fluoropyridin-3-amine

2-Chloro-5-fluoropyridin-3-amine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Pharmaceutical Intermediate

Used in the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antivirals, or anti-inflammatory drugs.

The halogenated pyridine scaffold is prevalent in medicinal chemistry due to its metabolic stability and bioactivity potential.

2. Agrochemical Synthesis

Acts as a building block in the development of herbicides, fungicides, and pesticides.

Fluoro- and chloro-substituents improve lipophilicity and biological potency.

3. Cross-Coupling Reactions

The chlorine atom can undergo Suzuki, Buchwald-Hartwig, or Stille coupling reactions for further substitution.

The amine group enables amide bond formation and heterocyclic ring construction.

✅ Versatile Functional Groups

The combination of –NH₂, –Cl, and –F provides multiple reactive handles for chemical synthesis.

✅ High Reactivity

Facilitates coupling reactions and derivatization for complex molecule construction.

✅ Useful Scaffold

Pyridine ring systems are core components in a wide range of bioactive compounds.

✅ Electron-Withdrawing Effects

Halogens modulate the electronic nature of the molecule, useful for tuning activity in drug and agrochemical design.

2-Chloro-5-fluoropyridin-3-amine (CAS 884495-37-8) is a highly valuable intermediate in medicinal and agrochemical chemistry, offering multifunctional reactivity due to its halogenated pyridine backbone and amine group. Its role in complex synthesis makes it a go-to choice for building biologically active molecules.

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