CAS · 637031-93-7
Product Overview
3,3-Difluorocyclobutanamine hydrochloride is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | FCC VII |
|---|---|
| Odor | Floral and fruity fragrance |
| Appearance | Colorless oily transparent liquid |
| Assay by GLC | 98% min |
| Refractive Index (20℃) | 1.4300 to 1.4340 |
| Relative Density (25/25℃) | 0.8580 to 0.8630 |
| Acid value | 1% max |
Applications
3,3-Difluorocyclobutanamine hydrochloride (CAS 637031-93-7) is a highly specialized fluorinated intermediate used primarily in pharmaceutical research and advanced chemical synthesis. Its main applications are in the preparation of bioactive molecules, particularly drug candidates where the difluorocyclobutane motif contributes to metabolic stability, lipophilicity modulation, and conformational control. The hydrochloride salt form improves solubility, stability, and ease of handling, making it suitable for laboratory-scale studies as well as scale-up processes. This compound plays a key role in the synthesis of small-molecule drugs, enzyme inhibitors, and other fluorinated analogs in medicinal chemistry.
Benefits
The benefits of 3,3-Difluorocyclobutanamine hydrochloride are rooted in its structural and functional properties. The incorporation of two fluorine atoms within the cyclobutane ring significantly alters electronic and steric characteristics, enhancing bioavailability and resistance to metabolic degradation. The amine group provides a versatile handle for derivatization, enabling straightforward incorporation into a wide range of chemical frameworks. Additionally, the hydrochloride form ensures improved storage stability and reproducibility in synthesis. Together, these features make it a powerful tool for developing next-generation pharmaceuticals with optimized pharmacological profiles.
Conclusion
In conclusion, 3,3-Difluorocyclobutanamine hydrochloride is an essential fluorinated building block in drug discovery and fine chemical synthesis. Its unique combination of fluorinated cyclobutane structure and reactive amine functionality allows for the efficient creation of stable, potent, and innovative bioactive molecules. By supporting advancements in medicinal chemistry and chemical development, it plays a pivotal role in shaping modern therapeutic innovation.
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