CAS · 184357-46-8
Product Overview
3,6,9,12,15,18-Hexaoxanonadecan-1-amine is a high-purity polyethylene-glycol supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Light yellow liquid |
|---|---|
| Purity | 97% min |
| Homologue impurity | 0.5% max |
Applications
3,6,9,12,15,18-Hexaoxanonadecan-1-amine is a polyethylene glycol (PEG)-based amine widely used in pharmaceutical, biochemical, and materials science applications. Its primary amine functionality allows it to act as a reactive building block for conjugation with carboxylic acids, activated esters, aldehydes, or other electrophiles, facilitating the synthesis of PEGylated drugs, peptides, proteins, and small molecules. The hexaethylene glycol chain improves water solubility and reduces aggregation, making it ideal for drug delivery systems, bioconjugation, and protein modification. It is also used in polymer chemistry and materials science as a hydrophilic linker or spacer for surface functionalization, hydrogels, and nanoparticle modification.
Benefits
The benefits of 3,6,9,12,15,18-Hexaoxanonadecan-1-amine come from its chemical reactivity, hydrophilicity, and flexibility. The primary amine allows selective and efficient conjugation under mild conditions, preserving the activity of sensitive biomolecules. The hexaethylene glycol backbone enhances solubility, reduces steric hindrance, and provides flexibility, making it useful as a spacer in PEGylation and linker chemistry. It is chemically stable, compatible with both aqueous and organic media, and performs reliably in multi-step synthesis and bioconjugation protocols. These properties make it an effective intermediate for drug development, bioconjugation, and functional material design.
Conclusion
3,6,9,12,15,18-Hexaoxanonadecan-1-amine is a versatile PEGylated amine used in pharmaceuticals, bioconjugation, and materials science. Its combination of a reactive primary amine and a hydrophilic, flexible PEG chain enables selective conjugation, improved solubility, and structural adaptability. By facilitating efficient molecular modification and linker design, it serves as an essential building block in medicinal chemistry, bioconjugation, and advanced material applications.
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3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine丨CAS 869718-81-0
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