CAS · 55-21-0
Product Overview
Benzamide is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White or off-white crystal or powder |
|---|---|
| Assay (TLC) | 98.5% min |
| Melting Point | 125–128℃ (lit.) |
Applications
Benzamide (CAS 55-21-0) is a simple aromatic amide widely used in pharmaceuticals, organic synthesis, and biochemical research. In pharmaceuticals, it serves as a building block or intermediate for the synthesis of various therapeutic agents, including antipsychotic, antiemetic, and dopaminergic drugs. Its amide functionality allows it to participate in condensation reactions, forming more complex bioactive molecules. In organic synthesis, benzamide is used as a precursor for substituted benzamides, heterocycles, and functionalized aromatic compounds. In biochemical research, it is applied in enzyme inhibition studies and as a reagent in the preparation of radiolabeled or isotopically labeled derivatives for mechanistic studies. Additionally, it can be used in polymer and material chemistry for introducing amide functionalities into polymers or small molecules.
Benefits
The benefits of benzamide derive from its chemical simplicity, stability, and versatile reactivity. Its planar aromatic structure combined with the amide group allows predictable reactions in both acylation and condensation chemistry. Benzamide is relatively non-volatile, easy to handle, and compatible with a wide range of solvents and reaction conditions. Its stability under thermal and mild acidic or basic conditions makes it suitable for multi-step syntheses. Additionally, as a pharmacologically relevant scaffold, benzamide provides opportunities for structural modification to enhance potency, selectivity, and pharmacokinetic properties of derivatives in drug discovery.
Conclusion
In summary, benzamide is a versatile aromatic amide with broad applications in pharmaceuticals, organic synthesis, and biochemical research. Its applications include serving as an intermediate for drug synthesis, heterocycle preparation, and enzyme studies, while its benefits lie in chemical stability, predictable reactivity, and structural versatility. As both a simple and functional molecule, benzamide continues to be an essential building block for chemical and pharmaceutical innovation.
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