CAS · 84-80-0
Product Overview
Vitamin K1 is a high-purity vitamins supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade: | USP2024 |
|---|---|
| Appearance: | A clear, intense yellow, viscous, oily liquid, practically insoluble in water, sparingly soluble in alcohol, miscible with fatty oils. |
| Refractive index: | 1.523~1.526 |
| Identification: | UV spectrum: Test solution and standard solution exhibit maxima at the same wavelength and absorptivity at 248nm is within 3.0% Infrared spectrum: Conformance with standard spectrum. Reaction 1: A 1 in 20 solution of it in dehydrated Alcohol is neutral to litmus. Reaction 2: Test the limit of menadione |
| Impurities: | Maximum Single: 0.5% max Total: 1.0% max |
| Assay (Z and E isomers): | 97.0%–103.0% |
| Assay (Z isomer): | 21.0% max |
| Lead: | 3ppm max |
| Cadmium: | 1ppm max |
| Mercury: | 0.1ppm max |
| Arsenic: | 1ppm max |
| Total Plate Count: | 250cfu/g max |
| Yeast & Mold: | 100cfu/g max |
| E. coli (10g): | Negative |
| Salmonella: | Negative |
Applications
1. Pharmaceutical Industry
Hemorrhage Prevention and Treatment
Vitamin K1 is widely used to treat or prevent bleeding disorders caused by vitamin K deficiency. It is often administered to newborns shortly after birth to prevent hemorrhagic disease of the newborn.
Reversal of Anticoagulant Effects
Vitamin K1 is used as an antidote to counteract excessive bleeding from warfarin and other vitamin K antagonists, helping to restore normal clotting activity.
Support in Liver Disease and Biliary Obstruction
Since bile is essential for vitamin K absorption, patients with liver or bile duct disorders are often prescribed vitamin K1 to prevent deficiency-induced bleeding.
Vitamin K Deficiency Treatment
Used in conditions such as malabsorption syndromes, chronic antibiotic therapy, or prolonged fasting, where natural vitamin K intake or synthesis is impaired.
2. Nutraceuticals and Dietary Supplements
Bone Health Formulations
Vitamin K1 is included in supplements targeting osteoporosis prevention as it supports the action of osteocalcin, a bone matrix protein that requires carboxylation for proper function.
Cardiovascular Support
It is also used in formulations aiming to reduce arterial calcification by activating Matrix Gla Protein (MGP), which inhibits calcium buildup in blood vessels.
General Wellness Supplements
Vitamin K1 is commonly combined with other fat-soluble vitamins (A, D, and E) in multivitamin products to support overall health and wellness.
3. Food Fortification
Functional Foods and Infant Formula
Phylloquinone is added to infant formulas and other fortified food products to ensure adequate vitamin K intake, especially in populations at risk for deficiency.
Plant-Based Diet Support
As more consumers adopt vegan and vegetarian diets, supplementing or fortifying with vitamin K1 ensures that individuals meet recommended intake levels.
4. Cosmetics and Personal Care
Skin Care Products
Vitamin K1 is increasingly used in topical formulations for reducing dark circles, bruising, and rosacea. It may improve skin tone by enhancing microcirculation and reducing visible capillaries.
Post-Procedure Healing
In dermatology and cosmetic surgery, Vitamin K1 creams are used to help speed up healing and reduce bruising after procedures like laser treatments or injections.
5. Research and Laboratory Use
Biochemical Studies
Vitamin K1 is used in research on coagulation pathways, vitamin metabolism, and enzyme activity. It is also a tool for studying vitamin K-dependent proteins (VKDPs) in various organisms.
Plant Physiology
In plants, phylloquinone functions as an essential cofactor in photosystem I electron transport, making it important in plant biology studies.
Benefits
✅ Essential for Blood Clotting
Activates clotting factors II, VII, IX, and X, preventing dangerous internal and external bleeding.
Supports normal hemostasis after injury or surgery.
✅ Supports Bone Health
Promotes bone mineralization by activating osteocalcin, a key protein in bone matrix development.
May reduce fracture risk in the elderly when combined with calcium and vitamin D.
✅ Helps Prevent Arterial Calcification
Activates MGP to prevent calcium from being deposited in arteries.
Contributes to heart and vascular system health, particularly in aging populations.
✅ Safe for Newborns
Given routinely to newborns to prevent bleeding disorders.
Considered safe and effective when used as directed.
✅ Compatible with Vegan/Vegetarian Diets
Naturally derived from plants, making it suitable for those on restricted diets.
Conclusion
Vitamin K1 (CAS 84-80-0) is a crucial nutrient with diverse applications in medicine, nutrition, cosmetics, and research. Its central role in blood coagulation, bone metabolism, and vascular health makes it indispensable in both clinical and consumer health contexts. As science continues to uncover new functions of vitamin K-dependent proteins, the value of Vitamin K1 in therapeutic and preventative health is expected to grow further.
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