CAS · 181954-34-7
Product Overview
N2-Fmoc-L-2,3-diaminopropionic acid is a high-purity amino-acids supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White powder |
|---|---|
| Purity (HPLC) | 98% min |
| Melting Point | Around 170 °C |
| Mass Spectrum | In accordance with the standard |
Applications
N2-Fmoc-L-2,3-diaminopropionic acid (CAS 181954-34-7) is a protected amino acid widely used in peptide synthesis and medicinal chemistry. It serves as a building block for solid-phase peptide synthesis (SPPS), where the Fmoc (9-fluorenylmethoxycarbonyl) group protects the α-amino group, allowing sequential elongation of peptide chains. The N2-protected side-chain amine enables selective functionalization, cyclization, or conjugation reactions, making it valuable in the synthesis of cyclic peptides, peptidomimetics, and bioactive molecules. It is also used in the development of therapeutic peptides, enzyme inhibitors, and probes for biochemical research.
Benefits
The benefits of N2-Fmoc-L-2,3-diaminopropionic acid lie in its dual protection and stereochemical integrity. The Fmoc group is base-labile, allowing efficient deprotection during SPPS, while the N2-protected side chain prevents undesired side reactions and facilitates selective derivatization. Its L-configuration ensures the incorporation of stereochemically defined residues, which is crucial for peptide folding, biological activity, and structural studies. The compound is stable, soluble in common organic solvents, and compatible with standard coupling reagents, making it a reliable intermediate for automated or manual peptide synthesis.
Conclusion
N2-Fmoc-L-2,3-diaminopropionic acid is an essential protected amino acid used in peptide synthesis and medicinal chemistry. Its dual protection, stereochemical precision, and functional versatility allow for the efficient construction of cyclic peptides, peptidomimetics, and bioactive molecules. By providing stability, selectivity, and synthetic flexibility, it remains a critical building block in modern peptide research and therapeutic development.
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