CAS · 153433-21-7
Product Overview
PyOxim is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off-white solid |
|---|---|
| Purity (by HPLC) | 98% min |
| Water (K.F) | 0.5% max |
Applications
PyOxim is a highly efficient coupling reagent widely used in peptide synthesis and organic chemistry. It is primarily employed to activate carboxylic acids for amide bond formation, facilitating the synthesis of peptides, proteins, and peptide-based drugs. PyOxim is particularly valued in solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis, where it promotes rapid, high-yield coupling while minimizing racemization. Beyond peptides, it is used in the synthesis of small-molecule amides, esters, and other carboxyl-derived derivatives in medicinal chemistry and fine chemical research. Its high reactivity, water compatibility, and stability under standard conditions make it suitable for both laboratory-scale research and industrial peptide manufacturing.
Benefits
The benefits of PyOxim stem from its efficiency, stability, and low racemization profile. It enables rapid and high-yield formation of amide bonds, which is essential for synthesizing high-purity peptides and bioactive compounds. Its chemical stability and compatibility with various solvents allow for easy handling and reproducibility in multi-step syntheses. PyOxim also minimizes side reactions and epimerization, ensuring the integrity of chiral centers in amino acids and peptides. These properties improve synthetic efficiency, reduce purification requirements, and enhance overall productivity in peptide and amide synthesis. Its water-compatible nature further broadens its applicability in environmentally friendly and aqueous reaction conditions.
Conclusion
In summary, PyOxim is a versatile and efficient coupling reagent with applications in peptide synthesis, protein chemistry, and the preparation of amide and ester derivatives. Its benefits include rapid and high-yield coupling, low racemization, chemical stability, and solvent compatibility. By combining efficiency with reliability, PyOxim remains an essential reagent in pharmaceutical research, peptide manufacturing, and advanced organic synthesis.
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