CAS · 69388-84-7
Product Overview
Sulbactam sodium is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | USP39 |
|---|---|
| Appearance | White or off-white crystalline powder |
| Assay | 886 ~ 941 μg/mg |
| Identification | (1), (2) Complies |
| Solubility | Complies |
| Crystallinity | Complies |
| Water | 1.0% max. |
| Impurities A | 0.5% max. |
| Impurities B | 0.1% max. |
| Impurities C | 0.2% max. |
| Impurities D | 0.1% max. |
| Impurities E | 0.2% max. |
| Impurities F | 0.1% max. |
| Any individual unspecified impurity | 0.10% max. |
| Total impurities | 1.0% max. |
| Bacterial endotoxin | 0.17 EU/mg max. |
Applications
Clinical Antibacterial Agent
Sulbactam sodium is primarily used in combination with β-lactam antibiotics, such as ampicillin, to combat infections caused by β-lactamase-producing bacteria. This combination is marketed under the brand name Unasyn and is effective against a broad spectrum of pathogens, including both gram-positive and gram-negative bacteria, as well as anaerobes.
Pharmaceutical Research and Development
Employed in the development of new antibiotic formulations and in studies aimed at overcoming antibiotic resistance mechanisms. Sulbactam sodium serves as a model compound for designing novel β-lactamase inhibitors.
Cell Culture Applications
Recent studies have explored the use of sulbactam sodium in eukaryotic cell culture, where it may protect cerebral neurons against oxygen-glucose deprivation by up-regulating astrocytic GLT-1 expression via the p38 MAPK signaling pathway.
Plant Biotechnology
Used in Agrobacterium-mediated plant genetic modifications to suppress β-lactamase activity, thereby enhancing the efficacy of β-lactam antibiotics in plant transformation protocols.
Benefits
Enhanced Antibiotic Efficacy
By inhibiting β-lactamase enzymes, sulbactam sodium protects β-lactam antibiotics from degradation, thereby extending their spectrum of activity against resistant bacterial strains.
Broad-Spectrum Activity
The combination of sulbactam with ampicillin or other β-lactam antibiotics provides a wide-ranging antibacterial effect, making it suitable for treating various infections, including those of the respiratory tract, skin, and urinary system.
Established Clinical Use
Sulbactam sodium has a well-documented safety and efficacy profile, with established dosing regimens and a history of successful clinical applications.
Versatility in Research
Beyond its clinical applications, sulbactam sodium serves as a valuable tool in laboratory research, aiding in the study of antibiotic resistance mechanisms and the development of new therapeutic strategies.
Conclusion
Sulbactam Sodium (CAS 69388‑84‑7) is a pivotal β-lactamase inhibitor that, when combined with β-lactam antibiotics, significantly enhances their effectiveness against resistant bacterial strains. Its broad-spectrum activity, established clinical use, and versatility in research make it an indispensable component in both therapeutic and investigative settings. As antibiotic resistance continues to pose a global health challenge, sulbactam sodium remains a critical agent in the ongoing effort to combat bacterial infections.
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