CAS · 606130-90-9
Product Overview
13-Azido-2,5,8,11-tetraoxa-tridecane is a high-purity polyethylene-glycol supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Colorless clear liquid |
|---|---|
| Purity | 99% min |
| Homologue impurity | 0.5% max |
Applications
13-Azido-2,5,8,11-tetraoxa-tridecane is a functionalized polyethylene glycol (PEG) derivative featuring an azide group, widely used in bioconjugation, drug delivery, and materials science. Its azide functionality allows efficient and selective "click chemistry" reactions, including copper-catalyzed azide–alkyne cycloaddition (CuAAC) and strain-promoted azide–alkyne cycloaddition (SPAAC), facilitating the attachment of peptides, proteins, small molecules, polymers, and nanoparticles. The tetraethylene glycol chain provides water solubility, flexibility, and spacing between conjugated molecules, which is valuable in the design of PEGylated therapeutics, hydrogels, targeted drug delivery systems, and functional biomaterials. Additionally, it is employed in surface modification and chemical biology studies to label, immobilize, or functionalize biomolecules and nanomaterials.
Benefits
The benefits of 13-Azido-2,5,8,11-tetraoxa-tridecane come from its combination of azide reactivity, PEG-mediated solubility, and structural flexibility. The azide group enables highly selective and orthogonal conjugation under mild conditions, preserving the activity of sensitive biomolecules. The tetraethylene glycol backbone enhances water solubility, reduces aggregation, and provides a spacer that minimizes steric hindrance, improving target accessibility and bioavailability in PEGylated systems. Its chemical stability, compatibility with both aqueous and organic solvents, and reproducible performance make it a reliable intermediate for laboratory and industrial applications, including drug delivery and materials engineering.
Conclusion
13-Azido-2,5,8,11-tetraoxa-tridecane is a versatile and valuable PEG-azide derivative for bioconjugation, PEGylation, and functional material design. Its azide functionality and tetraethylene glycol chain enable selective, efficient conjugation while enhancing solubility, flexibility, and biocompatibility. By supporting precise molecular modification, improved bioavailability, and advanced material functionality, this compound plays an important role in pharmaceutical research, biomaterials engineering, and chemical biology.
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