CAS · 42924-53-8
Product Overview
Nabumetone丨42924-53-8 is a nonsteroidal anti-inflammatory drug (NSAID) used primarily for pain relief, inflammation reduction, and arthritis management. It is a prodrug, meaning it is metabolized in the body into its active form, 6-methoxy-2-naphthylacetic acid (6-MNA), which provides its therapeutic effects.
Product Specifications
| Property | Specification |
|---|---|
| Appearance | White or almost white crystalline powder |
| Assay (Anhydrous basis) | 97.0% to 102.0% |
| Solubility | Practically insoluble in water, freely soluble in acetone, slightly soluble in methanol |
| Identification | IR |
| Related Substances | |
| Impurity F | 0.3% max |
| Unspecified Impurities | 0.10% max |
| Sum of Impurities other than F | 0.5% max |
| Water | 0.2% max |
| Sulfated Ash | 0.1% max |
Applications
1. Treatment of Osteoarthritis and Rheumatoid Arthritis
● Long-term Pain Management:
Used to treat chronic joint pain and inflammation in arthritis patients.
● Reduces Stiffness and Swelling:
Helps improve mobility and joint function.
2. General Pain Relief and Anti-Inflammatory Effects
● Effective for Mild to Moderate Pain:
Used to relieve musculoskeletal pain, back pain, and soft tissue injuries.
● Lower Gastrointestinal Risk Compared to Other NSAIDs:
Nabumetone is less likely to cause stomach ulcers compared to other NSAIDs like ibuprofen and naproxen.
3. Potential Cardiovascular and Neurological Applications (Investigational Use)
● Explored for Neuroprotection:
Studied for its potential role in Alzheimer's disease and neuroinflammation.
● Possible Cardiovascular Benefits:
May reduce inflammation linked to heart disease and vascular disorders.
Benefits
1. Long-Lasting Anti-Inflammatory Action
● Provides once or twice-daily dosing, improving patient compliance.
2. Lower Risk of Gastrointestinal Side Effects
● Unlike traditional NSAIDs, nabumetone produces less stomach irritation and ulcer risk.
3. Effective for Chronic Pain Conditions
● Used in the long-term management of arthritis and inflammatory disorders.
Conclusion
Nabumetone丨42924-53-8 is a widely used NSAID for arthritis, pain relief, and inflammation control. Its long duration of action and lower gastrointestinal side effects make it a preferred choice for chronic pain management. Additionally, ongoing research suggests potential neuroprotective and cardiovascular applications.
Previous
Next