CAS · 51298-62-5
Product Overview
N-Nitro-L-arginine-methyl ester hydrochloride is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White or off-white crystalline powder |
|---|---|
| Purity (HPLC) | 98.0% min |
| Specific rotation (C=1 in MeOH) | +13° to +17° |
| Loss on drying | 0.5% max |
Applications
N-Nitro-L-arginine methyl ester hydrochloride (L-NAME) is primarily used as a biochemical tool and research compound in pharmacology and physiology. It serves as a selective inhibitor of nitric oxide synthase (NOS), allowing researchers to study the role of nitric oxide (NO) in cardiovascular, neurological, and immune systems. L-NAME is widely applied in experiments investigating blood pressure regulation, vascular tone, endothelial function, and inflammatory responses. It is also used in preclinical studies to model conditions such as hypertension, atherosclerosis, and other NO-related physiological or pathological processes.
Benefits
The benefits of N-Nitro-L-arginine methyl ester hydrochloride include its high specificity for NOS, which allows precise modulation of nitric oxide levels in experimental systems. By inhibiting NO synthesis, it enables detailed studies of vasodilation, neurotransmission, and immune regulation, providing insights into disease mechanisms and therapeutic targets. L-NAME is stable, soluble in aqueous solutions, and effective at low concentrations, making it convenient for laboratory use. Its reproducible pharmacological effects support reliable experimental outcomes and facilitate drug discovery and physiological research.
Conclusion
N-Nitro-L-arginine methyl ester hydrochloride is a valuable research tool for investigating the role of nitric oxide in health and disease. Its specificity, stability, and effectiveness make it essential for studies in cardiovascular, neurological, and immunological research. By enabling controlled inhibition of nitric oxide production, L-NAME continues to contribute to a deeper understanding of physiological processes and the development of potential therapeutic strategies.
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