CAS · 6366-70-7
Product Overview
N6-Cbz-L-Lysine benzyl ester hydrochloride is a high-purity amino-acids supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off-white powder |
|---|---|
| Assay | 98% – 102% |
| D-Isomer | 0.5% max |
| Water | 1% max |
| TLC | 0.5% Lys(Z) max |
| Single impurity | 0.3% max |
| Purity (HPLC) | 98% max |
Applications
N6-Cbz-L-Lysine benzyl ester hydrochloride is a protected amino acid derivative widely used as a key intermediate in peptide synthesis and pharmaceutical research. It is primarily employed in solid-phase and solution-phase peptide synthesis, where the carbobenzyloxy (Cbz) group protects the lysine side-chain amine and the benzyl ester safeguards the carboxyl group, allowing for selective reactions at other positions. This compound is essential in the preparation of bioactive peptides, therapeutic peptides, and peptidomimetics used in drug discovery and development. It is also utilized in research laboratories for studying peptide chemistry, structure–activity relationships, and advanced peptide modification techniques.
Benefits
N6-Cbz-L-Lysine benzyl ester hydrochloride offers significant advantages due to its dual protective groups, which provide high selectivity and stability during multi-step peptide synthesis. The Cbz group prevents undesired side reactions at the lysine amino group, while the benzyl ester protects the carboxyl terminus, facilitating controlled deprotection when needed. The hydrochloride form improves solubility in polar organic solvents, enhancing handling and reaction efficiency. Its high purity and reproducibility make it suitable for both small-scale laboratory research and large-scale pharmaceutical synthesis, ensuring consistent yields and reliable peptide quality.
Conclusion
N6-Cbz-L-Lysine benzyl ester hydrochloride is a versatile and essential intermediate in peptide synthesis and pharmaceutical development. Its benefits, including dual protection, chemical stability, solubility, and selectivity, make it indispensable for producing high-quality peptides and bioactive compounds. Continued use of this compound supports advancements in peptide therapeutics, medicinal chemistry, and innovative drug development.
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