CAS · 22832-87-7
Product Overview
Miconazole nitrate is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade: | USP-NF2023/EP11 |
|---|---|
| Appearance: | White or off-white crystalline powder |
| Assay (On dried basis): | 98~102.0% |
| Solubility: | Complies |
| Identification: | IR, UV |
| Optical rotation: | -0.1° to +0.1° |
| Related Substances: Impurity A (Deschlorobenzyl econazole): | 0.25% max |
| Impurity B (Miconazole quarternary salt): | 0.25% max |
| Impurity C (Miconazole benzyl analog): | 0.25% max |
| Impurity D: | 0.25% max |
| Impurity E: | 0.25% max |
| Impurity F (Econazole nitrate): | 0.25% max |
| Impurity G (Miconazole 2,6-isomer): | 0.25% max |
| Impurity H (Miconazole 2,5-isomer): | 0.25% max |
| Impurity I: | 0.25% max |
| Unknown Single impurity: | 0.1% max |
| Total Impurity: | 0.5% max |
| Melting Point: | 178~183℃ |
| Loss on drying: | 0.5% max |
| Residue on ignition: | 0.2% max |
| Residue solvents: Acetone: | 0.5% max |
| Ethanol: | 0.5% max |
Applications
Miconazole nitrate is a broad-spectrum antifungal agent widely used in pharmaceutical, veterinary, and personal care products. It is commonly formulated into creams, ointments, powders, sprays, and gels for the treatment of superficial fungal infections such as athlete's foot, ringworm, jock itch, and candidiasis. In veterinary medicine, it is applied to treat fungal infections in animals. Additionally, miconazole nitrate is used in oral gels and lozenges to manage oral thrush and mucosal fungal infections. It is also incorporated into over-the-counter antifungal products and some cosmetic formulations for its preservative and antimicrobial properties.
Benefits
Miconazole nitrate offers effective antifungal activity against a wide range of dermatophytes, yeasts, and some gram-positive bacteria, providing rapid relief from infection symptoms. Its local application minimizes systemic exposure, reducing potential side effects while maintaining high efficacy at the site of infection. The compound is chemically stable, compatible with various formulation bases, and has a well-established safety profile, making it reliable for both prescription and over-the-counter products. Its broad-spectrum activity, ease of formulation, and proven effectiveness make it a preferred choice for treating fungal infections.
Conclusion
Miconazole nitrate is a highly effective antifungal agent with extensive applications in human and veterinary medicine, as well as personal care products. Its broad-spectrum activity, safety, and compatibility with various formulations make it an essential ingredient for managing superficial fungal infections and maintaining skin and mucosal health.
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