CAS · 383-63-1
Product Overview
Ethyl trifluoroacetate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Colorless liquid |
|---|---|
| Purity | 99.5% min. |
| Water | 0.1% max. |
| Fluoride | 0.1% max. |
| Chloride | 0.1% max. |
| Sulphate | 0.1% max. |
Applications
1. Pharmaceutical Intermediate
Ethyl trifluoroacetate is widely used as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs).
Acts as a trifluoroacetylating agent, introducing trifluoromethyl groups into heterocycles and amines, which is important for modifying bioactivity and metabolic stability.
Used in the preparation of peptides, beta-lactam antibiotics, and other trifluoromethyl-containing drugs.
2. Agrochemical Synthesis
Plays a significant role in the production of herbicides, fungicides, and insecticides.
The trifluoromethyl group can enhance lipophilicity, chemical stability, and bioactivity of agrochemicals.
3. Organic Synthesis and Chemical Research
Serves as a fluorinated acylating agent in advanced organic transformations.
Useful for protecting amines or synthesizing trifluoroacetyl derivatives of amino acids, phenols, and alcohols.
Employed in metal-catalyzed reactions and as a reagent in asymmetric synthesis.
4. Material Science
Can be used in the functionalization of fluorinated polymers and high-performance coatings, especially where chemical resistance and thermal stability are important.
Benefits
✅ Introduction of Trifluoromethyl Group (–CF₃)
Enhances metabolic stability, lipophilicity, and electronic effects in both pharmaceutical and agrochemical molecules.
The –CF₃ group is known to influence bioavailability, membrane permeability, and binding affinity in drug candidates.
✅ Reactive and Selective Reagent
Ethyl trifluoroacetate reacts selectively with nucleophiles (e.g., amines, alcohols), making it an efficient reagent for selective functionalization.
Useful in mild reaction conditions, minimizing side products.
✅ Volatility and Ease of Removal
Its low boiling point (~75 °C) allows for easy removal after reaction, facilitating cleaner syntheses and simpler purification processes.
✅ Versatile Intermediate
Can serve both as a reagent and building block, making it attractive for complex molecule construction in synthetic chemistry.
Conclusion
Ethyl trifluoroacetate (CAS 383-63-1) is a valuable fluorinated reagent and intermediate widely used in pharmaceuticals, agrochemicals, and advanced organic synthesis. Its ability to introduce trifluoromethyl functionality significantly enhances the physicochemical and biological properties of target molecules. With benefits such as high reactivity, selectivity, and compatibility with various substrates, it plays a critical role in modern synthetic chemistry and applied material science.
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