CAS · 2743-38-6
Product Overview
Dibenzoyl-L-tartaric acid is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white to white powder or white crystal |
|---|---|
| Purity | 99% min |
| Water content | 0.5% max |
| Specific rotation | -117° to -123° |
| Clarity | Conforms |
Applications
1. Chiral Resolution Agent
Primary use is in the resolution of racemic amines or bases into their enantiomers.
Forms diastereomeric salts with chiral and racemic amines, allowing for:
Separation by crystallization
Recovery of individual enantiomers
Commonly used in:
Pharmaceutical synthesis (e.g., resolution of alkaloids, beta-blockers, or chiral intermediates)
Fine chemical production
2. Asymmetric Synthesis
Functions as a chiral auxiliary or chiral reagent in asymmetric reactions.
Enables enantioselective synthesis of compounds in research and development of APIs (active pharmaceutical ingredients).
3. Chiral Stationary Phase (CSP) Precursor
Used to modify silica gel or other supports to create chiral chromatography columns.
Effective in HPLC or SFC methods for enantiomeric separation.
4. Analytical Chemistry
Applied in chiral purity determination and enantiomeric excess analysis.
Helps identify or quantify enantiomers in complex mixtures, especially in drug development.
5. Custom Ligand Design
Acts as a chiral scaffold in the synthesis of ligands or catalysts for use in enantioselective catalysis (e.g., metal complexation or organocatalysis).
Benefits
✅ High Enantioselectivity
Its well-defined L-configuration and rigid diester structure make it highly effective in resolving a wide range of racemic amines.
Produces high yields of enantiomerically pure products with good selectivity.
✅ Broad Substrate Compatibility
Effective with various aliphatic, aromatic, and heterocyclic amines.
Applicable in both academic research and industrial-scale synthesis.
✅ Ease of Use and Recovery
Simple salt formation and crystallization protocols.
Recyclable after resolution, reducing process cost and waste.
✅ Supports Regulatory Compliance
Widely accepted in the pharmaceutical industry for chiral resolution of drug intermediates.
Enables production of optically pure APIs required by regulatory agencies.
✅ Chiral Purity Assurance
Plays a key role in ensuring stereochemical integrity in drug development.
Essential in producing enantiomer-specific medications, which can have dramatically different pharmacological effects.
Conclusion
Dibenzoyl-L-tartaric acid (CAS 2743-38-6) is a highly valuable chiral resolving agent and enantioselective synthesis tool. Its unique structure enables efficient resolution of racemic compounds, making it indispensable in pharmaceutical chemistry, asymmetric synthesis, and analytical separation. By providing high selectivity, broad compatibility, and reproducibility, it helps chemists and manufacturers produce optically pure and regulatory-compliant compounds essential for modern medicine and advanced materials.
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