CAS · 946075-13-4
Product Overview
Isavuconazonium sulfate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white to light yellow powder |
|---|---|
| Purity | 95% min |
| Solubility | Easily soluble in water and methanol |
| Moisture | 2% max |
| pH value | 2.0 - 4.0 max |
| SMA-A | 0.05% max |
| SMA-B | 0.05% max |
| SMA-C | 0.05% max |
| INB | 1% max |
| INC | 0.5% max |
| ISC-A | 0.3% max |
| ISC-B | 0.3% max |
| ISC-C | 0.5% max |
| ISC-E | 0.5% max |
| ISC-H | 0.5% max |
| ISC-G | 0.5% max |
| Total impurities | 3% max |
| Triethylamine | 0.5% max |
| Ethanol | 0.5% max |
| Isopropyl alcohol | 0.05% max |
| Dichloromethane | 0.5% max |
| Isopropyl ether | 0.5% max |
| Ethyl acetate | 0.02% max |
| Acetic acid | 1% max |
Applications
Isavuconazonium sulfate is a prodrug used in the pharmaceutical industry as an antifungal agent. Upon administration, it is rapidly converted in the body to its active form, isavuconazole, which treats invasive fungal infections such as aspergillosis and mucormycosis. It is formulated for both intravenous and oral delivery, providing flexibility in clinical treatment regimens. In drug development research, it serves as a model compound for studying prodrug strategies, antifungal efficacy, and pharmacokinetics.
Benefits
The key benefits of Isavuconazonium sulfate include its broad-spectrum antifungal activity, high oral bioavailability, and predictable pharmacokinetic profile. Its prodrug design enhances water solubility, allowing intravenous formulations without the use of solubilizing agents that can cause adverse reactions. The compound also exhibits fewer drug-drug interactions compared to older azole antifungals, improving safety in patients receiving multiple medications. Clinically, it enables effective treatment of life-threatening fungal infections with reduced toxicity and improved patient compliance.
Conclusion
Isavuconazonium sulfate is a clinically important antifungal prodrug that provides effective, safe, and versatile treatment for serious fungal infections. Its chemical and pharmacological design enhances solubility, bioavailability, and patient safety, making it a valuable option in both hospital and outpatient care. Continued use and research underscore its significance in modern antifungal therapy.
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