CAS · 22232-54-8
Product Overview
Carbimazole is a high-purity insecticides supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | A white or yellow-white crystalline powder |
|---|---|
| Assay: | 98%~102% |
| Identification: | Meet BP2015 standard |
| Melting Point: | 122–125°C |
| Sulphated Ash: | 0.1% max |
| Impurity A: | 0.5% max |
| Unspecified impurity: | 0.1% max |
| Total impurity: | 0.6% max |
| Solubility: | Slightly soluble in water, soluble in acetone and in alcohol |
| Loss on drying: | 0.5% max |
| Heavy Metals: | 10 ppm max |
| Mesh: | 100% should pass through 100# |
Applications
1. Treatment of Hyperthyroidism
Graves' Disease: Carbimazole is commonly prescribed to control excessive thyroid hormone production in autoimmune hyperthyroidism.
Toxic Multinodular Goiter: Used to manage patients with nodular thyroid disease causing hyperthyroidism.
Preparation for Thyroid Surgery or Radioiodine Therapy: Carbimazole helps normalize thyroid function before definitive treatments.
2. Thyrotoxic Crisis (Thyroid Storm) Management
While not used as a standalone treatment, carbimazole may be administered in combination with beta-blockers and corticosteroids to manage acute thyrotoxicosis, a potentially life-threatening complication of uncontrolled hyperthyroidism.
3. Pediatric Hyperthyroidism
Carbimazole is one of the few antithyroid medications suitable for children and adolescents, due to its efficacy and availability in manageable doses.
Benefits
Prodrug Advantage: Converted to methimazole, which is a more targeted inhibitor of thyroid peroxidase, reducing thyroid hormone production with lower risk of side effects.
Once-Daily Dosing: Long duration of action allows convenient administration, improving patient compliance.
Non-invasive Alternative: Offers a non-surgical and non-radioactive option for patients unsuitable for definitive therapies like thyroidectomy or radioactive iodine.
Good Tolerability: Well-tolerated in most patients when used at appropriate doses and with regular monitoring.
Reversible Effects: Unlike surgery or radioiodine, its effects are reversible, making it a safer first-line treatment, especially for children or during pregnancy.
Conclusion
Carbimazole (CAS 22232-54-8) is a valuable and effective antithyroid agent widely used in the management of hyperthyroidism. Its role in both short- and long-term treatment plans offers flexibility and safety, especially for patients who are not candidates for surgical or radioactive therapy. As a prodrug of methimazole, it allows for precise thyroid suppression with a manageable side effect profile. With its utility in adult and pediatric care alike, carbimazole continues to be a cornerstone in endocrine therapy for overactive thyroid conditions.
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