CAS · 2172373-55-4
Product Overview
5-VP-2-OME-U-CE-PHOSPHORAMIDITE is a high-purity nucleosides-nucleotides supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off-white solid |
|---|---|
| MS | To conform structure |
| 1H NMR | To conform structure |
| 31P NMR | 98.00% min |
| Purity (by HPLC) | 98.00% min |
| Solvent Content (by GC) | 0.50% max |
| Water Content (by KF) | 0.50% max |
Applications
5-VP-2-OME-U-CE-Phosphoramidite is primarily used as a key reagent in the chemical synthesis of modified oligonucleotides, including RNA and DNA analogs. It serves as a building block in automated solid-phase oligonucleotide synthesis, enabling the introduction of specific modifications at defined positions within the nucleic acid sequence. This makes it essential in the development of antisense oligonucleotides, siRNA, aptamers, and other nucleic acid therapeutics. Its chemical structure allows for high coupling efficiency and stability under synthesis conditions, facilitating the production of high-purity, sequence-specific oligonucleotides for research and pharmaceutical applications. It is also utilized in nucleic acid labeling, probe development, and molecular diagnostics.
Benefits
The main benefits of 5-VP-2-OME-U-CE-Phosphoramidite include its high reactivity and selectivity, which result in efficient incorporation into oligonucleotides with minimal side reactions. Its modified ribose structure enhances the stability of the resulting oligonucleotides against enzymatic degradation, improving their performance in therapeutic and diagnostic applications. The phosphoramidite chemistry allows for precise sequence control and reproducibility in synthesis, which is critical for producing consistent results in research and drug development. Additionally, it enables the design of nucleic acids with enhanced binding affinity, specificity, and functional properties, expanding the scope of nucleic acid-based technologies.
Conclusion
5-VP-2-OME-U-CE-Phosphoramidite is a highly specialized and valuable reagent in modern oligonucleotide synthesis. Its ability to introduce precise chemical modifications supports the development of advanced nucleic acid therapeutics, diagnostics, and molecular biology tools. By combining high coupling efficiency, stability, and sequence-specific incorporation, it streamlines research and production processes, making it an indispensable component in nucleic acid chemistry.
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