CAS · 550363-85-4
Product Overview
2-fluoro-5-formylbenzoic acid is a high-purity analytical-reagents supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White to off-white solid |
|---|---|
| Identification (by HPLC): | Retention time of the sample conforms main peak to that of the reference standard (±0.5 min) |
| Purity (by HPLC): | 98% min |
| Related substances: | 0.5% max |
Applications
2-Fluoro-5-formylbenzoic acid is primarily used in medicinal chemistry as a building block for the synthesis of pharmaceutical intermediates, enzyme inhibitors, and heterocyclic compounds. Its fluorine atom enhances metabolic stability and lipophilicity, while the aldehyde group allows for selective derivatization in multi-step syntheses. In organic synthesis, it is used for condensation reactions to form Schiff bases, imines, or other carbonyl-containing derivatives. The compound is also applied in material science and chemical research for designing functionalized molecules, polymers, and ligands with tailored electronic or steric properties. Additionally, it serves in structure-activity relationship (SAR) studies to explore how fluorine substitution influences biological activity and chemical reactivity.
Benefits
The benefits of 2-fluoro-5-formylbenzoic acid include its chemical versatility, selective reactivity, and enhanced stability. The aldehyde functionality allows for precise condensation or coupling reactions, while the fluorine atom contributes to electron modulation, metabolic resistance, and improved molecular binding in bioactive compounds. Its solubility in common organic solvents and stability under standard laboratory conditions make it easy to handle and incorporate into multi-step synthetic processes. The combination of reactive functional groups and structural rigidity enables efficient synthesis of complex molecules, enhancing productivity in medicinal and materials chemistry applications.
Conclusion
In summary, 2-fluoro-5-formylbenzoic acid is a multifunctional aromatic intermediate used in pharmaceutical synthesis, organic chemistry, and materials research. Its aldehyde and fluorine substituents provide selective reactivity, structural stability, and enhanced biological potential. With its versatility, stability, and utility in complex molecule construction, 2-fluoro-5-formylbenzoic acid is a valuable building block for developing bioactive compounds, functional materials, and advanced chemical architectures.
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