4-Methylumbelliferyl alpha-D-glucopyranoside
CAS 17833-43-1
CAS · 17833-43-1
Product Overview
4-Methylumbelliferyl alpha-D-glucopyranoside is a high-purity biochemical-reagents supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White or off-white powder |
|---|---|
| Purity (by HPLC) | 98.0% min |
| Loss on Drying | 0.3% max |
| Residue on Ignition | 0.3% max |
| 1H NMR | Comply to the structure |
| 13C NMR | Comply to the structure |
Applications
4-Methylumbelliferyl alpha-D-glucopyranoside is a fluorogenic substrate widely used in enzymology, biochemical research, and diagnostic assays. It is primarily employed to detect and quantify α-glucosidase activity in biological samples, which is essential for studying carbohydrate metabolism, lysosomal storage disorders, and microbial enzyme function. This compound is also used in high-throughput screening for drug discovery, where α-glucosidase inhibitors are evaluated for therapeutic potential in diabetes, obesity, and related metabolic disorders. Additionally, it finds applications in clinical diagnostics and research on plant and microbial glycosidases.
Benefits
The benefits of this substrate include high sensitivity, specificity, and rapid fluorescence response upon enzymatic cleavage. Its fluorogenic property enables easy detection of α-glucosidase activity even at low concentrations, making it suitable for both microplate-based assays and in vivo studies. The compound is stable under standard laboratory conditions, soluble in aqueous buffers, and compatible with various analytical instruments, facilitating reproducible and efficient enzyme activity measurements. Its versatility allows use in basic research, pharmaceutical development, and clinical diagnostics.
Conclusion
4-Methylumbelliferyl alpha-D-glucopyranoside is a valuable fluorogenic substrate for studying α-glucosidase activity in research, diagnostics, and drug development. Its benefits include high sensitivity, specificity, stability, and compatibility with diverse assay formats. By enabling precise enzyme monitoring, it supports metabolic research, therapeutic discovery, and clinical enzyme analysis.
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