CAS · 128107-47-1
Product Overview
Fmoc-D-Ser(tBu)-OH is a high-purity amino-acids supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White powder |
|---|---|
| Purity (HPLC) | 98% min |
| Optical Purity | 0.5% L-enantiomer max |
| Specific Rotation [a]20/D | -26° ± 3° (C=1 in EtOAc) |
| Melting Point | 125-140 °C |
| Clarity of solution | 0.3 gram in 2 ml DMF clear solution |
| Water Content (K.F.) | 1.0% max |
| Element analysis (CHN) | 5.0% max |
| Loss on drying | 1.0% (60 °C 2h) max |
| Kaiser Test | 0.05% max |
| TLC | 98% min |
| IR Spectrum | In accordance with the structure |
| Mass Spectrum | In accordance with the structure |
| NMR Spectrum | In accordance with the structure |
Applications
Peptide Synthesis
Serves as a protected D-serine building block in solid-phase peptide synthesis (SPPS) using the Fmoc/tBu strategy. Its Fmoc group safeguards the amine terminus, while the t-butyl ester protects the side-chain hydroxyl, allowing for sequential chain assembly and selective deprotection.
Drug Development & Bioactive Peptides
Used in the construction of D-serine–containing peptides and peptidomimetics. These often play a role in designing peptide-based therapeutics with enhanced biological stability and activity profiles.
Peptide Self-Assembly & Materials Science
Employed in research on self-assembling peptides and morphologically controlled biomaterials. Its Fmoc moiety promotes stacking interactions that drive ordered nanostructure formation.
Bioconjugation & Protein Engineering
Enables site-selective incorporation of D-serine residues in proteins or peptide-modified surfaces, aiding in targeted drug delivery, biosensor design, and tailored protein properties.
Benefits
Dual Protection with Easy Deprotection
Combines base-labile Fmoc protection (for the N-terminus) with acid-labile t-butyl protection (for the side chain), allowing orthogonal deprotection and precise control over synthesis steps.
High Purity & Enantiomeric Fidelity
Marketed at ≥98–99% purity and enantiomeric excess, ensuring high-quality peptide assembly without stereochemical ambiguity.
Stable Handling & Storage
Typically supplied as a white to off-white powder, stable when stored at low temperatures (e.g., 2–8 °C), enabling reliable use in laboratory workflows.
Facilitates Monitoring of Synthesis
The Fmoc group releases UV-active byproducts (like dibenzofulvene) upon deprotection, enabling real-time tracking and optimized synthesis efficiency.
Conclusion
Fmoc-D-Ser(tBu)-OH is a premium, dual-protected amino acid derivative indispensable for modern peptide synthesis. It combines selective protection strategies, excellent purity, and synthetic versatility to support the precise assembly of D-serine–inclusive peptides. Whether used in therapeutic design, biomaterials, or protein engineering, it provides chemists with a reliable and high-quality tool for advanced molecular construction.
Previous
Fmoc-N-Me-Arg(Pbf)-OH丨CAS 913733-27-4
Next