CAS · 16142-03-3
Product Overview
MPEG5-OCH2COOH is a high-purity polyethylene-glycol supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | light yellow liquid |
|---|---|
| Purity(by HNMR) | 95% min |
| Homologue impurity | 0.5% max |
Applications
MPEG5-OCH₂COOH is a functionalized methoxy polyethylene glycol derivative widely used in bioconjugation, drug delivery development, and advanced material engineering. With five ethylene glycol units, it provides moderate PEG chain length for enhancing water solubility and reducing aggregation of biomolecules and nanoparticles. The terminal carboxymethyl group enables efficient coupling to amines, peptides, proteins, polymers, and surfaces via EDC/NHS or other activation chemistries. MPEG5-OCH₂COOH is commonly used in the PEGylation of therapeutic peptides, enzymes, and small molecules to improve pharmacokinetics and reduce immunogenicity. It also serves as a linker or spacer in the synthesis of hydrogels, polymeric micelles, and smart drug delivery systems, contributing to improved stability, dispersibility, and functional performance. In surface modification, MPEG5-OCH₂COOH enhances hydrophilicity and minimizes nonspecific protein adsorption on nanoparticles, medical devices, and diagnostic platforms.
Benefits
The benefits of MPEG5-OCH₂COOH derive from its balance of hydrophilicity, flexibility, and reactive carboxyl functionality. The PEG5 chain offers significant solubility enhancement while maintaining manageable molecular size, making it ideal for applications requiring minimal steric hindrance with improved biocompatibility. PEGylation using this reagent can extend circulation time, increase bioavailability, and reduce clearance of therapeutic agents. The carboxyl group provides controlled and reliable conjugation, enabling the production of well-defined PEGylated derivatives with reproducible properties. Its excellent stability and compatibility across aqueous and organic systems make it suitable for scalable synthesis and versatile formulation design. Additionally, MPEG5-OCH₂COOH contributes to improved colloidal stability of nanoparticles and enhanced antifouling performance in biomedical surfaces.
Conclusion
MPEG5-OCH₂COOH is a highly useful PEG derivative that combines efficient conjugation capability with beneficial solubility and biocompatibility features. Its carboxyl functionality and optimized PEG chain length make it suitable for PEGylation, drug delivery, surface engineering, and materials science. By improving stability, reducing nonspecific interactions, and enhancing pharmacokinetic performance, MPEG5-OCH₂COOH plays an important role in the development of advanced biomedical technologies and high-performance chemical systems.
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