CAS · 84371-65-3
Product Overview
Mifepristone is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | CP2015 |
|---|---|
| Appearance | Light yellow crystal powder |
| Assay (HPLC, on the dried substance) | 98.5% min |
| Melting Point | 192°C to 196°C |
| Specific Optical Rotation | +124° to +129° |
| Loss on Drying (105°C, 3h) | 0.5% max |
| Total Impurities (HPLC) | 2.0% max |
| Maximum Unspecified Impurity (HPLC) | 1.0% max |
| Identification (By IR/UV) | The IR spectrum of sample complies with that of RS; maximum absorption at 304 nm and 260 nm |
| Granularity (D[90]) | 20μm max |
Applications
1. Medical Termination of Pregnancy
● Primary clinical use: Mifepristone丨CAS 84371-65-3 is FDA-approved for medical abortion during the first trimester (up to 10 weeks gestation), in combination with misoprostol.
● Mechanism: Blocks progesterone receptors, preventing the hormone from maintaining the uterine lining, leading to detachment of the embryo.
● When followed by misoprostol (a prostaglandin analogue), it induces uterine contractions and expulsion of pregnancy tissue.
2. Cushing's Syndrome (Hyperglycemia Management)
● Mifepristone is approved under the trade name Korlym for managing hyperglycemia secondary to Cushing's syndrome in adults with type 2 diabetes or glucose intolerance who are not candidates for surgery.
● Mechanism: Acts as a glucocorticoid receptor antagonist, helping mitigate the effects of excessive cortisol.
3. Research in Endocrinology and Oncology
● Studied in experimental settings for:
Breast cancer and endometrial cancer (as it inhibits progesterone signaling)
Psychiatric disorders (e.g., major depression with psychotic features) due to its glucocorticoid receptor blockade
Leiomyoma (fibroids) and endometriosis management
4. Emergency Contraception (Investigational Use)
● Although not its primary indication, low-dose mifepristone has been studied as a postcoital contraceptive, showing effectiveness in preventing ovulation and implantation when used within a specific timeframe.
Benefits
1. Non-Invasive Alternative to Surgery
● Mifepristone offers a safe, effective, and less invasive alternative to surgical abortion when used properly under medical guidance.
2. Receptor-Specific Activity
● High affinity for progesterone and glucocorticoid receptors, allowing targeted modulation with limited off-target hormonal effects at therapeutic doses.
3. Expanded Therapeutic Potential
● Its glucocorticoid antagonism opens avenues for treating metabolic disorders, psychiatric illness, and hormone-sensitive cancers.
4. Oral Bioavailability
● Mifepristone is well-absorbed orally and has a long half-life (~20–85 hours), which supports convenient dosing schedules.
Conclusion
Mifepristone丨CAS 84371-65-3 is a powerful and versatile pharmaceutical compound with well-established use in medical abortion and Cushing's syndrome, and promising investigational roles in oncology, reproductive health, and endocrinology. Its dual action as a progesterone and glucocorticoid receptor antagonist allows it to address complex hormone-dependent conditions while providing patients with non-invasive treatment options. Ongoing research continues to explore its broader therapeutic potential in various medical domains.
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