CAS · 58479-61-1
Product Overview
tert-Butylchlorodiphenylsilane is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Property | Specification |
|---|---|
| Appearance | Colorless bright liquid |
| Purity (GC) | 98.0% min |
| Tetrahydropyran (GC) | 1.5% max |
| Moisture | 0.3% max |
Applications
Tert-Butylchlorodiphenylsilane丨CAS 58479-61-1 is an organosilicon compound used primarily as an intermediate in organic synthesis and silicon-based material modification. It contains both reactive chlorosilane and bulky aromatic groups, making it valuable in specialty chemical production.
1. Synthesis of Organosilicon Compounds
● Acts as a chlorosilane reagent for introducing the diphenyl-tert-butylsilyl group onto alcohols, amines, and other nucleophilic centers.
● Used in the formation of silyl ethers as protecting groups for hydroxyl functions in multi-step organic syntheses.
2. Protecting Group Chemistry
● The tert-Butylchlorodiphenylsilane丨CAS 58479-61-1 (TBDPS) group derived from this compound is widely used in protecting alcohols due to its:
High stability to acidic and basic conditions
Steric hindrance, reducing unwanted side reactions
● Suitable for long reaction sequences or harsh conditions where other protecting groups might fail.
3. Pharmaceutical and Agrochemical Synthesis
● Used in the intermediate stages of synthesizing complex molecules in drug and pesticide development.
● Protects sensitive functional groups during key transformations.
4. Material Science and Surface Modification
● Reacts with hydroxylated surfaces (like silica or glass) to create hydrophobic coatings, altering surface energy and chemical properties.
● Applied in modifying silicon wafers or polymer surfaces in electronics and analytical devices.
Benefits
● High Selectivity: Allows for selective protection of primary vs. secondary alcohols in complex molecules.
● Chemical Stability: TBDPS-protected compounds exhibit excellent resistance to acidic and basic hydrolysis.
● Efficient Functional Group Transformation: The chlorosilane moiety enables straightforward coupling with nucleophiles under mild conditions.
● Versatility: Applicable in both small-molecule synthesis and materials modification.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.