CAS · 78281-72-8
Product Overview
Nepafenac is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Yellow crystalline powder |
|---|---|
| Purity | 99.0% min |
| Identification | IR/HPLC Conform |
| Particle size | D90 10μm max |
| Melting point | 183～187℃ |
| Single impurity | 0.1% max |
| Total impurities | 0.5% max |
| Residual solvent | Not find |
| Loss on drying | 1.0% max |
| Residue on ignition | 0.1% max |
| Heavy metal | 10ppm max |
| Bacteria | 1000cfu/g max |
| Mould | 1000cfu/g max |
| Escherichia coli | Not allowed |
Applications
1. Ophthalmic Anti-inflammatory Agent
Nepafenac is widely used as a topical ocular NSAID for the treatment and prevention of:
Postoperative inflammation and pain associated with cataract surgery.
Macular edema following cataract surgery in diabetic patients.
Noninfectious anterior uveitis, in some off-label cases.
2. Prodrug for Enhanced Ocular Penetration
Nepafenac is converted by intraocular hydrolases to amfenac, its active form, after corneal absorption.
The prodrug nature enhances corneal permeability, ensuring better drug delivery to intraocular tissues compared to other NSAIDs.
Benefits
✅ Superior Ocular Penetration
Due to its lipophilic structure, nepafenac easily crosses the cornea, providing more effective intraocular delivery.
✅ Targeted Activation
Its conversion to the active form (amfenac) occurs primarily in ocular tissues, minimizing systemic exposure and side effects.
✅ Effective Inflammation Control
Inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis to alleviate pain, redness, and swelling.
✅ Extended Duration with Once-Daily Formulations
Available in once-daily (0.3%) and thrice-daily (0.1%) eye drop formulations, improving patient compliance.
✅ Compatible with Other Eye Treatments
Often used in combination with antibiotics or corticosteroids post-surgery to ensure comprehensive ocular protection.
Conclusion
Nepafenac (CAS 78281-72-8) is a highly effective ophthalmic NSAID that stands out for its superior ocular bioavailability and targeted anti-inflammatory action. Its role as a prodrug allows it to deliver active medication directly where it's needed, minimizing systemic effects while efficiently managing postoperative pain and inflammation. Especially useful following cataract surgery, nepafenac contributes to better patient recovery, reduced complications, and improved visual outcomes. Its balance of efficacy, tolerability, and convenient dosing makes it a preferred choice among ocular anti-inflammatory therapies.
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