CAS · 6939-23-7
Product Overview
N-tert-Butylglycine hydrochloride is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off white crystalline or powder |
|---|---|
| Identification (HPLC) | The retention time of the major peak in the chromatogram of the sample preparation corresponds to that in the chromatogram of standard preparation. |
| Purity (HPLC) | 99% min |
| Largest single impurity | 0.5% max |
| Total impurity | 1% max |
| Water | 1% max |
Applications
N-tert-Butylglycine hydrochloride is widely used as a chiral building block and intermediate in organic synthesis and pharmaceutical research. It is primarily applied in the synthesis of peptidomimetics, peptide derivatives, and other biologically active molecules where steric hindrance from the tert-butyl group can influence conformational stability and receptor selectivity. This compound is also valuable in asymmetric synthesis as a chiral auxiliary or reagent, facilitating the production of enantiomerically pure compounds. Additionally, it finds applications in medicinal chemistry for the development of enzyme inhibitors, drug candidates, and other fine chemical intermediates that require precise stereochemistry and functional group control.
Benefits
The key benefits of N-tert-Butylglycine hydrochloride stem from its sterically bulky tert-butyl group and amino acid functionality. The tert-butyl moiety can enhance molecular stability, influence conformational properties of peptides, and improve selectivity in receptor interactions. Its hydrochloride salt form ensures high solubility, ease of handling, and stability, which are advantageous for laboratory and industrial synthesis. Furthermore, it allows for controlled reactivity in multi-step syntheses, enabling chemists to efficiently produce high-purity, enantiomerically defined intermediates for pharmaceuticals and fine chemicals.
Conclusion
N-tert-Butylglycine hydrochloride is a valuable chiral amino acid intermediate with broad applications in peptide synthesis, asymmetric synthesis, and medicinal chemistry. Its combination of steric bulk, solubility, and functional versatility makes it an essential tool for designing stable, selective, and high-purity bioactive molecules. By enabling precise control over molecular structure and reactivity, it supports the development of advanced pharmaceuticals and fine chemical products.
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