CAS · 288-14-2
Product Overview
Isoxazole is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Colorless to yellow liquid |
|---|---|
| Purity (GC): | 97% min |
| Water (KF): | 1% max |
Applications
1. Pharmaceutical Industry
Core structure in drug design: Isoxazole rings are found in numerous bioactive molecules, including antibiotics, anti-inflammatory agents, antipsychotics, and anticancer drugs.
Examples include drugs like valdecoxib (a COX-2 inhibitor) and leflunomide (an immunosuppressive agent).
The isoxazole moiety often improves the pharmacokinetic and pharmacodynamic properties of drug candidates.
2. Agrochemical Industry
Isoxazole derivatives serve as active ingredients in herbicides, fungicides, and insecticides.
Compounds such as isoxaflutole are widely used in crop protection.
3. Organic Synthesis
Used as a versatile building block or intermediate for the synthesis of heterocycles, pharmaceuticals, and other fine chemicals.
Its aromatic nature and heteroatoms make it suitable for selective functionalization.
Isoxazole can undergo ring-opening, substitution, and cycloaddition reactions.
4. Materials Science
Incorporated into organic electronic materials such as OLEDs, due to its electron-withdrawing character.
Used in designing novel polymers and ligands for catalysis.
Benefits
1. Stability and Aromaticity
Isoxazole is stable due to its aromatic system, which facilitates chemical modification without ring degradation.
2. Versatile Chemical Reactivity
The heteroatoms (N and O) provide sites for hydrogen bonding and coordination with metals, enhancing biological activity and catalytic properties.
3. Pharmacological Importance
The isoxazole ring can improve drug bioavailability, metabolic stability, and receptor binding affinity.
4. Environmental Benefits in Agrochemicals
Many isoxazole-based agrochemicals exhibit targeted activity with reduced environmental toxicity.
5. Synthetic Utility
Enables the synthesis of complex molecular architectures via efficient synthetic routes.
Conclusion
Isoxazole (CAS 288-14-2) is a key heterocyclic compound extensively used in pharmaceuticals, agrochemicals, organic synthesis, and materials science. Its aromatic and heteroatomic nature makes it invaluable for creating biologically active molecules and advanced materials with optimized properties. The broad utility and versatility of isoxazole continue to drive its importance in chemical research and industrial applications.
Previous
Next