CAS · 1005500-75-3
Product Overview
N-Ethynyl-N,4-dimethylbenzenesulfonamide is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off white to light brown powder |
|---|---|
| Purity (HPLC) | 97% min |
| Melting Point | 74–80 °C |
Applications
N-Ethynyl-N,4-dimethylbenzenesulfonamide is primarily used as a chemical intermediate in organic synthesis, pharmaceutical research, and material science. Its ethynyl and sulfonamide functional groups make it valuable for constructing bioactive molecules, heterocyclic compounds, and polymer precursors. In medicinal chemistry, it is applied to design and synthesize potential drug candidates, particularly molecules that require a sulfonamide pharmacophore for biological activity. The compound is also utilized in research to study alkyne reactivity, click chemistry applications, and the development of novel functional materials or ligands for catalysis, allowing for exploration of structure–activity relationships and synthetic methodologies.
Benefits
N-Ethynyl-N,4-dimethylbenzenesulfonamide offers several advantages in chemical and pharmaceutical applications. Its dual-functional ethynyl and sulfonamide groups enable versatile reactions, including coupling, cycloaddition, and nucleophilic substitution, facilitating multi-step synthetic strategies. The presence of a para-methyl group provides steric and electronic effects that can enhance selectivity and stability during chemical transformations. Its well-defined structure allows predictable reactivity, reproducibility, and efficient incorporation into complex molecules. Additionally, the compound's versatility supports rapid synthesis of derivative libraries, aiding drug discovery, materials development, and advanced organic research.
Conclusion
N-Ethynyl-N,4-dimethylbenzenesulfonamide is a versatile intermediate used in pharmaceuticals, organic synthesis, and materials science. Its reactive ethynyl and sulfonamide groups, combined with structural stability, make it a valuable building block for constructing bioactive molecules and functional materials. Overall, it supports efficient synthesis, structural diversification, and innovative research applications in chemical and pharmaceutical development.
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