CAS · 3140-73-6
Product Overview
2-Chloro-4,6-dimethoxy-1,3,5-triazine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White crystalline powder |
|---|---|
| Purity: | 99.0% min |
| Melting point: | 71~78℃ |
| Moisture: | 0.1% max |
Applications
1. Peptide Synthesis
● CDMT is widely used as a coupling reagent for peptide bond formation.
● It facilitates the conversion of carboxylic acids to activated esters, which then react with amines to form amide bonds.
● Preferred for solid-phase peptide synthesis (SPPS) due to its mild reaction conditions and high yields.
2. Activation of Carboxylic Acids
● CDMT is employed to activate carboxylic acids into reactive intermediates, such as triazine esters, that readily undergo nucleophilic substitution.
● Useful in forming esters, amides, and lactones in complex organic synthesis.
3. Pharmaceutical and Biochemical Applications
● Utilized in the synthesis of drug intermediates, bioactive molecules, and protein conjugates.
● Enables selective modification of biomolecules without harsh reagents or high temperatures.
4. Polymer and Materials Chemistry
● Acts as a crosslinking agent or functionalizing group in polymers containing carboxyl or amino functionalities.
● Enhances compatibility and reactivity in coatings, adhesives, and functional materials.
Benefits
✅ High Reactivity with Carboxylic Acids
● 2-Chloro-4,6-dimethoxy-1,3,5-triazine丨CAS 3140-73-6 provides efficient activation under mild conditions, avoiding racemization-a crucial factor in chiral synthesis.
✅ Mild and Clean Reactions
● Does not generate toxic byproducts; easy to remove residual materials post-reaction.
● Compatible with a wide range of solvents and functional groups.
✅ Enhanced Selectivity
● Offers better selectivity compared to traditional reagents (e.g., DCC or EDC) in forming amide bonds or acylated compounds.
✅ Useful in Aqueous or Organic Media
● CDMT-based reactions can be conducted in both aqueous and organic solvents, offering versatility in lab-scale and industrial processes.
✅ Improves Yield and Efficiency
● Often leads to higher coupling efficiency, reducing the need for excess reagents or repeated purification steps.
Conclusion
2-Chloro-4,6-dimethoxy-1,3,5-triazine丨CAS 3140-73-6 is a powerful and selective activation reagent ideal for amide and ester synthesis, especially in peptide chemistry. Its efficient reactivity, mild conditions, and clean conversion pathways make it a go-to choice for synthetic chemists working in drug development, materials science, and bioconjugation.
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