CAS · 2106-02-7
Product Overview
2-Chloro-4-fluoroaniline is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Colorless to light yellow liquid |
|---|---|
| Purity (GC) | 99% min |
| Boiling Point | 192 °C |
| Density | 1.219 g/mL at 25 °C |
| Water | 0.5% max |
Applications
2-Chloro-4-fluoroaniline (CAS 2106-02-7) is an aromatic amine widely used as an intermediate in the synthesis of dyes, pharmaceuticals, agrochemicals, and specialty chemicals. Its chloro and fluoro substituents make it a key building block for preparing heterocyclic compounds, herbicides, insecticides, and other bioactive molecules. In medicinal chemistry, it is used to synthesize substituted aniline derivatives that serve as precursors for drugs with anticancer, antiviral, or antimicrobial activity. Additionally, 2-chloro-4-fluoroaniline is employed in the production of azo dyes, pigments, and fluorescent materials due to its reactivity in coupling and substitution reactions.
Benefits
The benefits of 2-chloro-4-fluoroaniline arise from its dual halogen substitution and amino functionality. The chloro and fluoro groups enhance chemical stability and influence electronic properties, enabling selective transformations and improved reactivity in cross-coupling, condensation, and nucleophilic substitution reactions. Its amino group allows further functionalization, facilitating the synthesis of a wide range of derivatives. The compound is chemically stable, soluble in common organic solvents, and compatible with standard reaction conditions, making it a reliable and efficient intermediate for multi-step syntheses in pharmaceuticals, agrochemicals, and materials science.
Conclusion
2-Chloro-4-fluoroaniline is a versatile intermediate widely used in pharmaceuticals, agrochemicals, and dye production. Its combination of amino functionality and dual halogen substitution allows selective reactivity, chemical stability, and structural versatility. By supporting efficient synthesis of bioactive molecules, functional dyes, and specialty chemicals, 2-chloro-4-fluoroaniline continues to be an important building block in modern chemical and pharmaceutical applications.
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