CAS · 2967-66-0
Product Overview
Methyl 4-trifluoromethylbenzoate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Description | Colorless transparent liquid |
|---|---|
| Assay (methyl 4-(trifluoromethyl)benzoate) | 99% min (GC) |
| Assay (4-(trifluoromethyl)benzoic acid) | 0.50% max (GC) |
| Other impurities | 0.50% (GC) |
| Moisture (KARL FISHER) | 0.10% max |
Applications
Methyl 4-trifluoromethylbenzoate is a valuable intermediate in organic synthesis, especially in the creation of compounds with specialized electronic and chemical properties. Its unique trifluoromethyl (–CF₃) group attached to the aromatic ring imparts distinct characteristics that are useful in pharmaceutical, agrochemical, and material science applications. In pharmaceuticals, this compound serves as a precursor for the synthesis of bioactive molecules, particularly those aimed at modulating receptors or enzymes. The trifluoromethyl group is known to enhance the metabolic stability and lipophilicity of drug candidates, making it useful for the design of potent and selective therapeutic agents. In agrochemicals, Methyl 4-trifluoromethylbenzoate is used to develop more effective pesticides, herbicides, and fungicides, where the trifluoromethyl group improves the potency and environmental stability of these compounds. The compound also finds application in the production of high-performance materials and specialty chemicals, including fluorinated plastics, coatings, and fragrances, where the trifluoromethyl substitution imparts unique properties such as increased chemical resistance and enhanced solubility.
Benefits
The key benefits of Methyl 4-trifluoromethylbenzoate arise from the incorporation of the trifluoromethyl group, which significantly enhances the compound's physical and chemical properties. The –CF₃ group increases the lipophilicity of the molecule, improving its ability to cross lipid membranes, a property that is highly advantageous in drug development, especially for oral bioavailability and target specificity. This substitution also improves the compound's metabolic stability, making drugs more resistant to enzymatic breakdown, which can prolong their efficacy. In agrochemical applications, the trifluoromethyl group enhances the environmental stability of pesticides, ensuring longer-lasting effectiveness under diverse conditions. Additionally, this fluorine substitution imparts remarkable chemical resistance to the compound, making it suitable for use in harsh environments, such as in high-performance plastics and coatings. Its use in fragrances and specialty chemicals benefits from its ability to create distinct, long-lasting scents and contribute to the formulation of durable, high-quality materials.
Conclusion
Methyl 4-trifluoromethylbenzoate (CAS 2967-66-0) is a highly versatile compound with significant applications in pharmaceuticals, agrochemicals, and material sciences. The trifluoromethyl group attached to the aromatic ring imparts unique properties, including enhanced lipophilicity, metabolic stability, and chemical resistance, which make it an important building block for the development of potent and selective drug candidates, as well as effective agrochemicals. Its role in the creation of high-performance materials and specialty chemicals, such as fluorinated plastics, coatings, and fragrances, further underscores its broad utility. The compound's ability to modulate molecular properties and improve the efficacy and stability of various products ensures its continued importance in diverse industrial and research applications.
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