CAS · 64872-77-1
Product Overview
Butoconazole nitrate is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance / Description | White or almost white crystalline powder; odorless or almost odorless |
|---|---|
| Identification | IR spectrum matches the reference standard |
| Loss on drying | 1.0% max |
| Related Substance | 2.0% max |
| Residue on ignition | 0.1% max |
| Assay | 98.0% ～ 102.0% of C19H17Cl3N2SHNO3, calculated on dried basis |
| Particle Size Distribution (PSD, D90%) | 10 micron max |
Applications
Butoconazole nitrate (CAS 64872-77-1) is a broad-spectrum antifungal agent primarily used in pharmaceutical formulations for the treatment of vaginal yeast infections. It is applied in creams, gels, and suppositories to inhibit the growth of Candida species by interfering with fungal cell membrane synthesis. In addition to its clinical use, butoconazole nitrate is employed in pharmaceutical research to study azole antifungal mechanisms, drug resistance, and structure–activity relationships (SAR) within the imidazole class of antifungal compounds. Its well-characterized profile also makes it a reference standard in the development of new antifungal agents.
Benefits
The benefits of butoconazole nitrate stem from its potent antifungal activity, broad-spectrum efficacy, and favorable pharmacokinetic properties. Its nitrate salt form enhances solubility and stability in topical formulations, ensuring effective drug delivery to the affected site. The compound selectively inhibits fungal cytochrome P450 enzymes responsible for ergosterol synthesis, minimizing systemic side effects while providing rapid symptomatic relief. Its long-lasting local action reduces the required dosing frequency, improving patient compliance. Additionally, its chemical stability and compatibility with various excipients make it suitable for formulation in creams, gels, and suppositories.
Conclusion
In summary, butoconazole nitrate is a clinically important antifungal agent used in topical treatments and pharmaceutical research. Its applications include therapy for vaginal candidiasis, antifungal mechanism studies, and drug development, while its benefits lie in potent local activity, solubility, stability, and patient-friendly dosing. With these properties, butoconazole nitrate remains a key compound in antifungal therapy and pharmaceutical development.
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