CAS · 154229-18-2
Product Overview
Abiraterone acetate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | USP2024 |
|---|---|
| Appearance | White or off-white powder |
| Assay (as-is basis) | 98.0–102.0% |
| Solubility | Should comply with regulations |
| Identification (IR) | The IR absorption spectrum of the sample should be concordant with that of the reference standard |
| Identification (HPLC) | The retention time of the major peak of the sample solution corresponds to that in the chromatogram of the standard solution |
| Water | 0.25% max |
| Residue on ignition | 0.1% max |
| α-Epoxyabiraterone acetate | 0.25% max |
| β-Epoxyabiraterone acetate | 0.25% max |
| Abiraterone | 0.20% max |
| Abiraterone ethyl ether | 0.20% max |
| Abiraterone isopropyl ether | 0.20% max |
| Unspecified impurities | 0.10% max |
| Total impurities | 0.80% max |
Applications
Abiraterone acetate (CAS 154229-18-2) is a steroidal compound used primarily in pharmaceutical and clinical research related to hormone-dependent conditions. It functions as a prodrug that is converted in vivo to abiraterone, an inhibitor of CYP17 (17α-hydroxylase/C17,20-lyase), a key enzyme involved in androgen biosynthesis. As such, it is widely applied in the study, development, and manufacture of therapies targeting androgen-driven diseases, particularly advanced prostate cancer. Abiraterone acetate is also used in pharmacological research to investigate steroid metabolism, androgen signaling pathways, and endocrine regulation. In addition, it serves as a reference standard and active pharmaceutical ingredient (API) in formulation development, quality control, and regulatory studies within the pharmaceutical industry.
Benefits
The benefits of abiraterone acetate arise from its targeted mechanism of action, favorable bioavailability as a prodrug, and well-defined steroidal structure. By selectively inhibiting androgen biosynthesis at multiple sources, it enables effective suppression of androgen levels beyond conventional approaches. The acetate ester improves oral absorption and pharmacokinetic performance compared with the active metabolite alone. Its high specificity for CYP17 supports predictable pharmacological behavior, while its chemical stability allows reliable formulation and storage. These attributes make abiraterone acetate a robust and effective compound for therapeutic use, drug development, and advanced endocrine research.
Conclusion
Abiraterone acetate is an important steroidal pharmaceutical compound with well-established applications in androgen-related therapy and endocrine research. Its prodrug design, targeted enzyme inhibition, and favorable pharmacological profile support effective treatment strategies and reliable drug development. By enabling precise control of androgen biosynthesis, abiraterone acetate continues to play a significant role in modern pharmaceutical science and clinical therapeutics.
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