CAS · 128446-36-6
Product Overview
beta-Cyclodextrin methyl ethers is a high-purity cyclodextrin-derivatives supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White or almost white powder, odorless, slightly sweet. Freely soluble in water and methanol, soluble in ethanol and ethylene glycol, almost insoluble in cyclohexane and ethyl acetate. |
|---|---|
| Assay (on the dried basis): | 98% min. |
| Specific rotation: | +154° to +165° |
| Water solution pH: | 5.0 ~ 7.5 |
| Clarity of solution: | 2.5g/25ml water solution is clear |
| Light-absorbing impurities: | Between 230 and 350 nm, absorbance ≤ 1.0 Between 350 and 750 nm, absorbance ≤ 1.0 |
| Average degree of substitution: | 7.0 ~ 13.3 |
| Loss on drying: | 7.0% max. |
| Beta cyclodextrin: | 0.2% max. |
| Residue on ignition: | 0.5% max. |
| Heavy metal: | 10 ppm max. |
| Chloride: | 0.2% max. |
| Total aerobic microbial count: | 1000 cfu/g max. |
| Total combined molds and yeasts count: | 100 cfu/g max. |
| Escherichia coli: | Absent |
Applications
1. Pharmaceutical Industry
Solubilizing Agent: Methylated β-CD increases the solubility of hydrophobic drugs by forming inclusion complexes.
Bioavailability Enhancer: Improves absorption and stability of drugs in oral, injectable, and topical formulations.
Stabilizer: Protects labile drug molecules from hydrolysis, photodegradation, and oxidation.
Often used in nasal and pulmonary drug delivery systems for rapid systemic uptake.
2. Cosmetics and Personal Care
Carrier for Fragrances and Actives: Enables sustained release and improved stability of perfumes, vitamins, and antioxidants.
Formulation Aid: Enhances texture and solubility of products containing otherwise insoluble actives.
3. Food and Flavor Industry
Used to encapsulate flavors and aromas to prevent volatility and degradation.
Improves the shelf-life of sensitive compounds such as essential oils and sweeteners.
Can mask unpleasant tastes and odors in food products.
4. Analytical Chemistry
Used as a chiral selector in high-performance liquid chromatography (HPLC) for enantiomer separation.
Aids in improving resolution and specificity in GC or capillary electrophoresis.
5. Environmental and Industrial Applications
Pollutant Remediation: Used to trap and extract hydrophobic pollutants or toxic organic compounds from aqueous systems.
Catalysis: Serves as a host molecule to immobilize or transport catalysts in green chemistry applications.
Benefits
Superior Water Solubility: Compared to native β-cyclodextrin, methylation significantly enhances solubility, expanding its range of use in aqueous systems.
Enhanced Inclusion Complexation: The methylated structure improves interaction with a broader range of hydrophobic molecules.
Stabilization of Sensitive Compounds: Protects guest molecules from degradation due to light, heat, or oxygen.
Low Toxicity: Modified cyclodextrins are generally considered safe for use in food and pharmaceutical applications (depending on degree of substitution and regulatory limits).
Customizability: Degree of methylation can be tuned to suit specific application needs.
Conclusion
beta-Cyclodextrin methyl ethers丨CAS 128446-36-6 are versatile and effective cyclodextrin derivatives with broad utility across pharmaceuticals, food, cosmetics, and environmental science. Their enhanced solubility and ability to form stable inclusion complexes with hydrophobic compounds make them essential tools in modern formulation science.
Would you like example applications or formulation protocols using this compound?
Previous
Gamma-Cyclodextrin丨CAS 17465-86-0
Next