Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride
CAS 76308-26-4
CAS · 76308-26-4
Product Overview
Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white or white crystalline powder |
|---|---|
| Purity | 98% min |
| HPLC | The retention time of major peak in sample. Preparation should be concordant with the retention time of major peak in standard in the test of assay by HPLC |
| IR | IR spectrum of the sample should be concordant with that of working standard spectrum |
| Single impurity | 0.5% max |
| Water | 0.5% max |
Applications
This compound is primarily used as an intermediate in the synthesis of active pharmaceutical ingredients (APIs) and bioactive molecules. Its chiral cyclohexylamine moiety is key for the construction of stereochemically defined drugs, including central nervous system agents, analgesics, and other therapeutic compounds. The ester group allows further functionalization through hydrolysis, amidation, or reduction, enabling the preparation of derivatives with improved pharmacological properties. In medicinal chemistry, it is employed in structure–activity relationship (SAR) studies to optimize potency, selectivity, and metabolic stability of drug candidates. Additionally, this compound is used in chemical research for preparing chiral building blocks, exploring amine-based transformations, and synthesizing heterocyclic scaffolds.
Benefits
The key benefits of Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride include its stereochemical purity, chemical reactivity, and stability in hydrochloride form. The trans configuration of the cyclohexyl ring ensures predictable stereochemical outcomes in downstream synthesis, which is critical for pharmacologically active compounds. The primary amine allows versatile functionalization, while the ester group provides a handle for modifications to fine-tune solubility, lipophilicity, or biological activity. Its hydrochloride salt enhances water solubility, simplifies handling, and improves storage stability. The compound's structural rigidity and multifunctionality make it an efficient and reliable intermediate in multi-step synthetic pathways.
Conclusion
Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride is a versatile chiral intermediate widely used in pharmaceutical synthesis and organic chemistry. Its combination of a trans-aminocyclohexyl scaffold and ester functionality provides stereochemical precision, chemical reactivity, and functional versatility, making it essential for the development of APIs and bioactive molecules. As the demand for stereochemically defined intermediates grows in modern drug discovery, this compound remains a valuable building block for medicinal chemistry and chemical research.
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