6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido2,3-dpyriMidin-7(8H)-one
CAS 1016636-76-2
CAS · 1016636-76-2
Product Overview
6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido2,3-dpyriMidin-7(8H)-one is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White to Light yellow powder |
|---|---|
| Purity: | 98.5% min |
| Identification: | Infrared identification: The infrared absorption spectrum of the sample has characteristic absorption peaks at 1602±5 cm⁻¹, 1568±5 cm⁻¹, 1433±5 cm⁻¹, 1308±5 cm⁻¹, 1199±5 cm⁻¹, 791±5 cm⁻¹ |
| Loss on drying: | 0.5% max |
| Related substances: | Intermediate II: 0.3% max 2-Bromine Intermediate III: 0.5% max Any other individual impurity: 0.2% max Total impurities: 1.5% max N-bromosuccinimide and succinimide: 0.1% max |
| Residue solvents: | n-Hexane: 0.029% max Acetic acid: 0.5% max Methyl isobutyl ketone: 0.45% max DMF: 0.088% max Dichloromethane: 0.06% max |
Applications
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one is a highly functionalized heterocyclic compound commonly used as an intermediate in medicinal chemistry and pharmaceutical research. Its structure, featuring bromine, chlorine, and a cyclopentyl substituent on a fused pyrido-pyrimidine scaffold, makes it ideal for the synthesis of kinase inhibitors, antiviral agents, and other bioactive heterocycles. Researchers utilize it to construct complex molecules for drug discovery programs targeting cancer, inflammatory diseases, and metabolic disorders. Additionally, it is applied in structure-activity relationship (SAR) studies to optimize biological activity and selectivity of lead compounds, often serving as a precursor in multi-step organic syntheses involving cross-coupling, nucleophilic substitution, and cyclization reactions.
Benefits
The compound offers significant advantages due to its multiple reactive sites and rigid heterocyclic framework. The bromine atom allows for selective palladium-catalyzed cross-coupling reactions, while the chlorine atom provides further functionalization possibilities, enabling stepwise construction of diverse derivatives. Its cyclopentyl and methyl groups contribute to improved solubility, steric control, and molecular stability, which are critical for designing drug-like molecules. Moreover, the fused pyrido-pyrimidinone core imparts thermal and chemical stability, ensuring reliable performance in synthetic transformations and medicinal chemistry applications. Its well-defined structure facilitates reproducible reactions, making it an efficient and versatile building block for advanced pharmaceutical research.
Conclusion
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one is a valuable intermediate in the design and synthesis of biologically active heterocyclic compounds. Its multifunctional, halogenated heterocyclic framework enables selective and versatile chemical modifications, supporting drug discovery and medicinal chemistry efforts. With its stability, reactivity, and adaptability, this compound is a critical tool for creating novel therapeutic candidates and optimizing lead molecules in pharmaceutical research.
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