5,6,7,8-Tetrahydronaphthalene-1-carboxylic acid
CAS 4242-18-6
CAS · 4242-18-6
Product Overview
5,6,7,8-Tetrahydronaphthalene-1-carboxylic acid is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White or almost white crystalline powder |
|---|---|
| Purity | 99% min |
| Assay | Calculated by dry product; content of C11H12O2: 98% ~ 101% |
| Melting point | 148 – 152°C |
| Loss on drying | 1% max |
| 1-Naphthoic acid | 0.3% max |
| 1,2,3,4-Tetrahydro-1-naphthoic acid | 0.3% max |
Applications
5,6,7,8-Tetrahydronaphthalene-1-carboxylic acid is an aromatic carboxylic acid derivative widely used in pharmaceutical research, organic synthesis, and material science. It serves as a key intermediate for the synthesis of bioactive molecules, heterocyclic compounds, and functionalized aromatic systems. In drug discovery, it is applied to construct scaffolds for cardiovascular, neurological, and anti-inflammatory therapeutics, where the tetrahydronaphthalene core provides structural rigidity and hydrophobicity. In organic synthesis, it functions as a building block for esterification, amidation, and cyclization reactions, enabling the formation of complex molecules and derivatives. Additionally, it is used in materials chemistry for the preparation of specialty polymers, ligands, and functionalized aromatic frameworks in advanced chemical research.
Benefits
The benefits of 5,6,7,8-Tetrahydronaphthalene-1-carboxylic acid arise from its stable tetrahydronaphthalene backbone, reactive carboxyl functionality, and synthetic versatility. The hydrogenated naphthalene ring imparts chemical stability, hydrophobic character, and structural rigidity to target molecules. Its carboxylic acid group allows selective activation and coupling reactions, supporting multi-step syntheses with high yields and reproducibility. The compound is compatible with common organic solvents and reagents, facilitating diverse reaction pathways, including esterification, amidation, and cross-coupling. Its defined molecular structure and purity ensure consistent performance in pharmaceutical, synthetic, and materials chemistry applications.
Conclusion
5,6,7,8-Tetrahydronaphthalene-1-carboxylic acid is a versatile intermediate for organic synthesis, pharmaceutical research, and materials development. Its reactive carboxyl group, stable tetrahydronaphthalene core, and compatibility with multiple reaction pathways make it an essential building block for bioactive molecules, functionalized derivatives, and advanced chemical frameworks. By supporting efficient synthesis, structural optimization, and innovative material applications, this compound continues to play a significant role in modern chemical and pharmaceutical research.
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