2-Hydroxy-4-(trifluoromethyl)pyrimidine

2-Hydroxy-4-(trifluoromethyl)pyrimidine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

2-Hydroxy-4-(trifluoromethyl)pyrimidine is a highly valuable heterocyclic compound widely used as a building block and intermediate in pharmaceutical, agrochemical, and materials chemistry. Its trifluoromethyl-substituted pyrimidine structure provides unique electronic and steric properties, making it an essential precursor in the synthesis of antiviral, anticancer, and antibacterial agents. In medicinal chemistry, it is utilized to design nucleoside analogs and other bioactive heterocycles where fluorination enhances metabolic stability, lipophilicity, and binding affinity. In agrochemical development, it serves as an intermediate for producing herbicides, fungicides, and insecticides with improved bioactivity and environmental persistence. Additionally, this compound is applied in the synthesis of functional materials, such as fluorinated dyes, polymers, and coordination complexes, where its electron-withdrawing trifluoromethyl group imparts chemical stability, UV resistance, and altered physicochemical properties. Its reactive hydroxy group allows further functionalization, enabling versatile chemical modifications for tailored applications in both research and industrial settings.

The benefits of 2-Hydroxy-4-(trifluoromethyl)pyrimidine stem from its chemical stability, reactivity, and fluorinated molecular structure. The trifluoromethyl group enhances lipophilicity and metabolic stability, which improves the pharmacokinetic properties of drug candidates and increases the bioavailability of agrochemicals. Its hydroxy functionality provides a reactive site for selective derivatization, allowing the design of structurally diverse compounds with targeted biological or material properties. The presence of fluorine also imparts resistance to oxidation, UV degradation, and hydrolysis, extending the shelf life and performance of formulations. In research and development, it serves as a versatile intermediate that facilitates efficient and precise synthetic routes, reducing the number of steps and improving overall yield. Moreover, its compatibility with various reaction conditions, solvents, and reagents enhances flexibility in both small-scale laboratory synthesis and industrial production.

2-Hydroxy-4-(trifluoromethyl)pyrimidine (CAS 104048-92-2) is a multifunctional heterocyclic intermediate that plays a critical role in pharmaceuticals, agrochemicals, and functional material synthesis. Its unique combination of a reactive hydroxy group and electron-withdrawing trifluoromethyl substituent provides enhanced chemical stability, metabolic resilience, and versatility for derivative synthesis. By enabling the creation of high-performance bioactive molecules and materials, this compound continues to be an indispensable tool for chemists and formulators seeking innovative, stable, and efficient solutions in research and industry.

Previous

Bromopentacarbonylmanganese丨CAS 14516-54-2

Next

2,3,4,5,6-Pentafluoroaniline丨CAS 771-60-8