CAS · 1006-39-9
Product Overview
2-Bromo-4-fluoroacetophenone is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Colourless or light yellow liquid |
|---|---|
| Purity | 98% min |
Applications
2-Bromo-4-fluoroacetophenone (CAS 1006-39-9) is a halogenated aromatic ketone widely used as a building block in organic synthesis and pharmaceutical research. Its bromine and fluorine substituents provide sites for selective cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings, enabling the construction of complex aromatic and heteroaromatic frameworks. In medicinal chemistry, it serves as a key intermediate in the synthesis of bioactive molecules, including antiviral, anticancer, and enzyme inhibitor candidates. Additionally, it is used in the preparation of functional materials, dyes, and specialty chemicals, where the combination of electron-withdrawing halogens and a reactive ketone group contributes to chemical versatility and stability.
Benefits
The benefits of 2-Bromo-4-fluoroacetophenone arise from its dual halogen substituents and reactive carbonyl functionality. The bromine atom enables efficient metal-catalyzed cross-coupling, while the fluorine atom enhances the metabolic stability, lipophilicity, and electronic properties of downstream compounds. Its ketone group allows for nucleophilic addition, condensation, and enolate chemistry, providing diverse pathways for derivatization. The compound is stable under standard storage conditions and soluble in common organic solvents, which facilitates handling and integration into multi-step synthetic processes. These features make it an efficient, versatile, and reliable intermediate for both laboratory-scale and industrial applications.
Conclusion
2-Bromo-4-fluoroacetophenone is a valuable halogenated ketone intermediate widely used in pharmaceuticals, materials science, and organic synthesis. Its combination of bromine, fluorine, and ketone functionality provides multiple reactive sites, enabling selective transformations and structural diversification. By supporting efficient and versatile synthetic strategies, it continues to be a critical building block in the development of bioactive compounds, functional materials, and specialty chemicals.
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