CAS · 104227-87-4
Product Overview
Famciclovir丨CAS 104227-87-4 is an orally administered antiviral medication that is a prodrug of penciclovir. After ingestion, it is rapidly converted in the body to penciclovir, which inhibits viral DNA synthesis. It is widely used for the treatment of infections caused by herpes viruses.
Product Specifications
| Grade | USP |
|---|---|
| Appearance | White or off-white crystalline powder |
| Assay (on dried basis) | 98.0~102.0% |
| Identification | A/B Conforms: A. Infrared absorption B. HPLC retention time |
| Dimethylaminopyridine | 0.05% max |
| Penciclovir | 0.50% max |
| Famciclovir related compound A | 0.20% max |
| Famciclovir related compound B | 0.60% max |
| N-7 isomer of famciclovir | 0.10% max |
| N-acetyl famciclovir | 0.10% max |
| Deoxychlorofamoclovir | 0.20% max |
| Propionyl famciclovir | 0.15% max |
| 6-chlorofamiclovir | 0.15% max |
| 6-alkylaminofaiclovir | 0.10% max |
| Any other unspecified impurity | 0.10% max |
| Total impurities | 1.0% max |
| Loss on drying | 0.5% max |
| Residue on ignition | 0.1% max |
| Methanol | 3000 ppm max |
| Ethyl acetate | 5000 ppm max |
| Dichloromethane | 600 ppm max |
| Cyclohexane | 3880 ppm max |
Applications
1. Treatment of Herpes Simplex Virus (HSV) Infections
Effective in treating genital herpes, cold sores (herpes labialis), and other HSV-related infections.
Helps to reduce the duration and severity of outbreaks.
2. Management of Herpes Zoster (Shingles)
Used to treat shingles caused by the varicella-zoster virus.
Can help alleviate symptoms and speed recovery.
3. Prevention of Recurrent HSV Infections
Used prophylactically to reduce the frequency of recurrent genital herpes episodes in patients with frequent outbreaks.
Benefits
✅ Oral Bioavailability
Famciclovir is well absorbed when taken orally, improving patient compliance compared to intravenous antivirals.
✅ Selective Viral Targeting
Specifically inhibits viral DNA polymerase, minimizing effects on host cells.
✅ Reduced Side Effects
Generally well tolerated with fewer side effects than some other antivirals.
✅ Effective Against Multiple Herpes Viruses
Active against HSV-1, HSV-2, and varicella-zoster virus.
Summary
Famciclovir丨CAS 104227-87-4 is a potent oral antiviral prodrug used primarily for treating and preventing herpes virus infections such as genital herpes and shingles. Its good oral bioavailability and selective antiviral action make it a preferred treatment option with a good safety profile.
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Conclusion
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