CAS · 804-63-7
Product Overview
Quinine sulphate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade: | BP Grade |
|---|---|
| Appearance: | White crystalline powder with no special odor. |
| Content (calculated as dry product): | 98.0% – 101.0% |
| Solubility: | Slightly soluble in water, significantly soluble in hot water and ethanol (96%) |
| TLC: | The spots in the chromatogram obtained from the test solution of TLC are consistent in position, color, and size with the spots obtained from the control solution |
| Ammonium bromide coloration: | Green |
| Fluorescence reaction: | When examined under 366nm ultraviolet light, a strong blue fluorescence appears, which almost completely disappears after adding 1mL hydrochloric acid |
| Sulfate reaction: | Solution should produce sulfate reaction |
| PH: | Should meet the standards |
| Solubility display: | Solution S is transparent and the color is not thicker than the reference solution GY6 |
| PH: | 5.7 – 6.6 |
| Specific rotation: | -237 ~ -245° |
| Other Cinchona alkaloids, dihydroquinidine: | 10.0% max |
| Other impurities before quinine elution: | 5.0% max |
| Other impurities: | 2.5% max |
| Dry weight loss: | 3.0% – 5.0% |
| Sulfate ash content: | 0.1% max |
Applications
1. Pharmaceutical Industry
a. Antimalarial Agent
Quinine sulfate has long been used as a primary treatment for malaria, especially:
Plasmodium falciparum, including strains resistant to chloroquine
Severe or complicated malaria (in combination with other drugs)
It works by interfering with the parasite's ability to digest hemoglobin, thus killing the parasite within red blood cells.
b. Antipyretic and Analgesic
Historically, quinine sulfate was also used to:
Reduce fever
Relieve pain, especially in febrile diseases like influenza
c. Treatment of Nocturnal Leg Cramps
Quinine sulfate has been used off-label to manage restless leg syndrome and nighttime leg cramps, though its use is restricted in many countries due to side effects.
2. Flavoring and Beverage Industry
a. Bittering Agent
Quinine sulfate is a natural bitter compound, used in:
Tonic water (providing its characteristic taste)
Bitter-flavored beverages and liqueurs
Though quinine hydrochloride is more common in food uses, the sulfate form may be used in certain regional formulations.
3. Chemical and Analytical Uses
a. Fluorescent Standard
Due to its strong fluorescence in UV light, quinine salts (especially in acidic solution) are sometimes used as a:
Standard for photoluminescence calibration
Reference in fluorescence spectroscopy
Benefits
✅ Effective Antimalarial Treatment
Quinine sulfate remains a life-saving drug in regions where artemisinin resistance is emerging, and is often used when modern therapies are unavailable or ineffective.
✅ Natural Origin
Derived from Cinchona bark, quinine sulfate is naturally occurring, making it a historically important phytochemical in medicine.
✅ Dual Purpose: Medical and Food Grade
Its role in both pharmaceuticals and the beverage industry gives quinine sulfate a broad commercial relevance.
✅ Fluorescent Properties
The strong blue fluorescence makes it a useful tool in analytical chemistry and laboratory research.
Conclusion
Quinine sulfate (CAS 804-63-7) is a multifunctional compound with strong applications in medicine, food and beverage, and analytical science. While its use in malaria treatment remains vital in certain parts of the world, it is also valued for its bitter flavoring properties and fluorescence characteristics. When used responsibly and under regulation, quinine sulfate continues to be a chemically and commercially significant substance.
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