CAS · 29836-26-8
Product Overview
Octyl-beta-D-glucopyranoside丨29836-26-8: Overview, Applications, and Benefits
Octyl-β-D-glucopyranoside, with the Chemical Abstracts Service (CAS) number 29836-26-8, is a non-ionic surfactant and glycoside. It consists of a glucose molecule (β-D-glucopyranose) linked to an octyl chain via a glycosidic bond. This compound is widely used in biochemistry, molecular biology, and industrial applications due to its mild detergent properties, ability to solubilize membrane proteins, and biocompatibility.
Product Specifications
| Property | Specification |
|---|---|
| Appearance | White powder |
| Purity by TLC | 99% min |
| Assay (HPLC) | 98% min |
| Solubility | Easily soluble in water. Clear to very slightly hazy colorless to faint yellow solution |
| Identification | IR and TLC |
| MS and NMR | Should comply |
| A (UV, at 260nm) | 0.3 max |
| pH | 5 to 8 |
| Optical Activity [α]20D (c=1, CH3OH) | -25 deg to -30 deg |
| Optical Activity [α]20D (c=5, H2O) | -30 deg to -35 deg |
| Loss Weight on Dryness | 0.5% max |
| Residue on Ignition | 0.5% max |
| Alpha-Isomer | 0.5% max |
| n-Octanol | 0.05% max |
Applications
1. Biochemistry and Molecular Biology:
- Protein Solubilization: Octyl-β-D-glucopyranoside is commonly used to solubilize membrane proteins while preserving their native structure and function. It is particularly useful for extracting integral membrane proteins for structural and functional studies.
- Membrane Protein Crystallization: It is used in the crystallization of membrane proteins for X-ray crystallography and cryo-electron microscopy (cryo-EM) studies.
- Cell Lysis: It is employed in cell lysis buffers to disrupt cell membranes and release cellular contents without denaturing proteins.
2. Biotechnology:
- Detergent in Protein Purification: Octyl-beta-D-glucopyranoside丨29836-26-8 is used in chromatography and other purification techniques to isolate proteins and other biomolecules.
- Liposome Preparation: It is used to prepare liposomes and other lipid-based delivery systems for drug delivery and vaccine development.
3. Industrial Applications:
- Emulsifier and Stabilizer: It is used in the formulation of cosmetics, personal care products, and cleaning agents due to its mild surfactant properties.
- Food Industry: It is used as an emulsifier and stabilizer in food products to improve texture and shelf life.
4. Research and Development:
- Model Surfactant: Octyl-β-D-glucopyranoside is used as a model surfactant in studies of micelle formation, membrane dynamics, and surfactant behavior.
- Enzyme Studies: It is used to study the activity and kinetics of membrane-bound enzymes.
Benefits
1. Mild Detergent Properties:
- Octyl-β-D-glucopyranoside is a mild, non-ionic detergent that effectively solubilizes membrane proteins without denaturing them, making it ideal for biochemical and structural studies.
2. Biocompatibility:
- Its biocompatibility and low toxicity make it suitable for use in biological and pharmaceutical applications.
3. Versatility:
- Its applications span biochemistry, biotechnology, industrial formulations, and research, highlighting its versatility.
4. Stability:
- Octyl-beta-D-glucopyranoside丨29836-26-8 is stable under a wide range of conditions, including pH and temperature variations, ensuring reliable performance in various applications.
5. Ease of Removal:
- It can be easily removed from protein solutions by dialysis or dilution, simplifying downstream processing.
Conclusion
Octyl-beta-D-glucopyranoside丨29836-26-8 is a versatile and widely used non-ionic surfactant with applications in biochemistry, biotechnology, industrial formulations, and research. Its mild detergent properties, biocompatibility, and stability make it an indispensable tool for solubilizing membrane proteins, preparing liposomes, and studying membrane dynamics. As research and technology continue to advance, Octyl-β-D-glucopyranoside will remain a key component in the development of new biotechnological and industrial applications. Proper handling and storage ensure its benefits are maximized while maintaining safety and efficacy.
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