CAS · 220620-09-7
Product Overview
Tigecycline is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Orange or orange yellow powder |
|---|---|
| Purity (HPLC) | 98% min. |
| Water | 5.0% max. |
| ImpC | 0.7% max. |
| ImpD | 0.9% max. |
| ImpE | 0.5% max. |
| ImpH | 0.8% max. |
| Any other single impurity | 0.5% max. |
| Total impurities | 3.0% max. |
| Chloromethane | 0.01% max. |
| Chloro-isopropane | 0.01% max. |
| Dimethyl sulfate | 0.01% max. |
| Diisopropyl sulfate | 0.01% max. |
Applications
Tigecycline is primarily used as a broad-spectrum antibiotic in the treatment of complicated bacterial infections, including skin and soft tissue infections, intra-abdominal infections, and community-acquired pneumonia. It belongs to the glycylcycline class and is effective against multidrug-resistant bacteria, including strains resistant to tetracyclines. In pharmaceutical research, Tigecycline is utilized to study antibiotic mechanisms, resistance pathways, and pharmacokinetics. The compound is also employed in the development and evaluation of combination therapies, drug delivery systems, and new antimicrobial agents. In laboratory studies, it serves as a reference compound for testing bacterial susceptibility and for exploring novel approaches to combat antibiotic-resistant pathogens.
Benefits
Tigecycline offers several benefits due to its broad-spectrum activity and unique mechanism of action. It effectively inhibits protein synthesis by binding to the bacterial ribosome, which reduces the risk of cross-resistance with other antibiotic classes. The compound demonstrates high potency against Gram-positive and Gram-negative pathogens, including multidrug-resistant strains, making it valuable in clinical settings where conventional antibiotics are ineffective. Its pharmacokinetic properties, including good tissue penetration and systemic distribution, support effective treatment of complicated infections. Additionally, Tigecycline's well-characterized chemical structure allows reproducible formulation and dosage, contributing to reliable clinical efficacy and safety.
Conclusion
Tigecycline is a critical antibiotic used for treating complex and multidrug-resistant bacterial infections. Its applications in clinical therapy and pharmaceutical research, combined with benefits such as broad-spectrum activity, potent efficacy, and reliable pharmacokinetics, make it an important tool in combating infectious diseases. The compound continues to support advances in antimicrobial therapy and the development of strategies to address antibiotic resistance.
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