CAS · 632-22-4
Product Overview
Tetramethylurea is a high-purity pesticide-intermediate supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Colorless to light yellow transparent liquid |
|---|---|
| Purity (GC) | 99.0% min |
| Water (KF) | 0.5% max |
Applications
1. Specialty Solvent in Organic Chemistry
● Tetramethylurea (TMU) is a highly polar, aprotic solvent commonly used in organic synthesis and nucleophilic substitution reactions.
● It is particularly useful for reactions involving ionic compounds or organometallic complexes, where high polarity and low nucleophilicity are advantageous.
2. Polymer and Material Science
● Used as a processing solvent for high-performance polymers, such as polyimides and polyaramides, due to its ability to dissolve otherwise insoluble materials.
● Applied in the production of membranes, films, and other advanced materials that require strong solvents for fabrication.
3. Electrolyte and Battery Research
● Investigated as a co-solvent or additive in electrolyte formulations for lithium batteries and other electrochemical applications, where its high dielectric constant enhances ionic conductivity.
4. Catalysis and Reaction Medium
● Tetramethylurea丨CAS 632-22-4 is used as a reaction medium in transition-metal-catalyzed reactions, such as palladium- or nickel-catalyzed couplings, due to its stability and solvent properties.
● Also used in phase-transfer catalysis and peptide coupling processes.
5. Peptide and Biochemical Research
● Occasionally employed in peptide synthesis and protein denaturation studies, thanks to its ability to disrupt hydrogen bonding and protein folding.
● Functions similarly to other chaotropic agents like urea and guanidinium salts.
Benefits
1. High Polarity and Dielectric Constant
● Offers excellent solvation for polar and ionic compounds, making it suitable for challenging or sensitive reactions.
● Its dielectric constant (~38) is significantly higher than many standard solvents, facilitating enhanced reactivity.
2. Thermal and Chemical Stability
● TMU is stable under a wide range of conditions, including elevated temperatures and exposure to basic or mildly acidic media.
3. Enhanced Reaction Efficiency
● Improves reaction rates and yields in several organic processes by better stabilizing transition states and solubilizing intermediates.
Conclusion
Tetramethylurea丨CAS 632-22-4 is a highly polar aprotic solvent with important roles in organic synthesis, material science, and electrochemistry. Its strong solvating ability, thermal stability, and compatibility with various reaction conditions make it a valuable tool in advanced chemistry and industrial research. However, due to health risks, it must be handled with care and appropriate safety protocols in place.
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