CAS · 302-95-4
Product Overview
Sodium deoxycholate is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Item | Specification |
|---|---|
| Appearance | White crystalline powder; Bitter taste, easy to absorb moisture |
| Purity | 98% min (In terms of dry products) |
| Melting Point | 350°C - 365°C |
| Identify | The solution should change from light red to purple red |
| Specific Rotation | +38° ~ +42.5° (dry) |
| Heavy Metal | 20 ppm max |
| Loss on Drying | 5% max |
| Light Transmittance | 20% min |
| CA | 1% max |
| Lithocholic Acid | 0.1% max |
| Unknown Single Impurity | 1% max |
| Total Impurities | 2% max |
Applications
1. Cell Biology and Biochemistry
● Cell Lysis and Membrane Disruption:
Commonly used to permeabilize or lyse cells, especially in the preparation of cell extracts or membrane protein studies.
Solubilizes membrane proteins while preserving their activity.
● Protein Extraction and Isolation:
Used in buffer systems for isolating nuclear, cytoplasmic, and membrane proteins.
Suitable for use in Western blot, ELISA, and other protein detection assays.
● RNA Extraction Protocols:
Included in lysis buffers to ensure effective disruption of cell membranes while preserving nucleic acids.
2. Microbiology
● Selective Agent in Culture Media:
Acts as a selective inhibitor for Gram-positive bacteria, allowing the growth of Gram-negative bacteria.
Used in MacConkey agar and other enteric bacterial media to differentiate and isolate intestinal pathogens like E. coli and Salmonella.
3. Pharmaceuticals and Medicine
● Bile Acid Replacement Therapy:
Sometimes included in formulations to aid in fat digestion and absorption in cases of bile acid deficiency.
● Fat Dissolution (Aesthetic Medicine):
Used in non-surgical fat reduction procedures (e.g., Kybella®) as a fat-dissolving agent, particularly in submental (under chin) fat treatments.
Acts by disrupting adipocyte membranes, leading to fat cell destruction.
4. Emulsifying Agent
● Used in formulations that require solubilization of lipophilic compounds, such as lipid-based drug delivery systems.
● Functions as an emulsifier in pharmaceutical and laboratory formulations.
Benefits
√ Efficient Membrane Disruptor
● Highly effective at disrupting lipid bilayers, enabling the extraction of hydrophobic and membrane-bound biomolecules.
√ Selective Microbial Agent
● Helps in bacterial isolation by suppressing undesired flora in culture media, improving specificity in diagnostic microbiology.
√ Versatile Surfactant
● Dual hydrophilic-lipophilic nature allows it to solubilize proteins, lipids, and drugs, aiding research and formulation development.
√ Aesthetic and Therapeutic Uses
● Proven efficacy in localized fat reduction, offering a non-invasive alternative to liposuction in cosmetic dermatology.
√ Biocompatible and Well-Studied
● As a derivative of naturally occurring bile acids, it is biologically relevant and biodegradable, with a strong track record of safety in controlled use.
Conclusion
Sodium deoxycholate丨CAS 302-95-4 is a powerful surfactant and biological tool, widely used in protein research, microbial diagnostics, and cosmetic medicine. Its ability to disrupt cell membranes makes it invaluable in cell lysis, bacterial media formulation, and non-surgical fat reduction procedures. With strong efficacy, broad applications, and biological compatibility, sodium deoxycholate is a versatile asset in both research and clinical settings.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.