CAS · 3543-75-7
Product Overview
Bendamustine hydrochloride is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Off-white to white solid |
|---|---|
| Purity: | 98% min |
| Acidity (pH): | 2.5–3.5 |
| Water: | 4.0%–6.0% |
| Chlorinity: | 24.0%–30.0% |
| Total Impurity: | 2.0% max |
Applications
Bendamustine hydrochloride (CAS 3543-75-7) is a chemotherapeutic agent widely used in oncology for the treatment of hematologic malignancies, including chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), and multiple myeloma. It functions as an alkylating agent, inducing DNA crosslinking that inhibits cancer cell replication and triggers apoptosis. In pharmaceutical research, it is utilized as a reference compound for studying antineoplastic mechanisms, combination therapies, and drug resistance in cancer cells. Bendamustine hydrochloride is also applied in clinical trials to evaluate novel dosing regimens, safety profiles, and synergistic effects with other chemotherapeutics or targeted therapies.
Benefits
The benefits of bendamustine hydrochloride derive from its dual mechanism of action, combining alkylating and antimetabolite-like properties. This allows it to effectively target cancer cells, including those resistant to conventional alkylating agents, while providing a relatively favorable safety profile compared to older chemotherapies. Its water-soluble hydrochloride form facilitates intravenous administration and precise dosing in clinical settings. Additionally, it has shown efficacy in both frontline and relapsed/refractory cases, improving progression-free survival and patient outcomes. Its ability to work synergistically with other drugs also expands treatment options for complex malignancies.
Conclusion
Bendamustine hydrochloride is a potent chemotherapeutic agent with significant applications in treating hematologic cancers. Its unique dual mechanism of action, solubility, and clinical versatility make it an important tool in oncology therapy and research. By effectively targeting resistant cancer cells and supporting combination treatments, bendamustine hydrochloride continues to play a critical role in cancer management and pharmaceutical development.
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