CAS · 53003-10-4
Product Overview
Salinomycin丨CAS 53003-10-4 is a polyether antibiotic originally isolated from the bacterium Streptomyces albus. It is widely recognized for its potent anticoccidial activity in veterinary medicine, especially in poultry. More recently, salinomycin has gained attention for its anti-cancer properties, particularly its ability to target cancer stem cells. Its chemical identification is denoted by CAS number 53003-10-4.
Product Specifications
| Appearance | White to off-white solid |
|---|---|
| Purity (HPLC) | 90% min |
| Identification (HPLC) | The retention time of the major peak of the sample solution corresponds to that of the standard solution |
| Content (HPLC, on anhydrous) | Test and report |
| Individual impurity (HPLC) | Test and report |
| Total impurities | Test and report |
| Residual solvent by TGA | Test and report |
| Residue on ignition | Test and report |
Applications
A. Veterinary Medicine: Anticoccidial Agent
Poultry Industry:
Salinomycin丨CAS 53003-10-4 prevents and controls coccidiosis, a parasitic disease caused by Eimeria species.
Used as a feed additive in broiler chickens and turkeys.
Cattle and other livestock:
Occasionally used to improve feed efficiency by altering ruminal fermentation, promoting growth.
B. Animal Growth Promoter
By modifying rumen microflora in cattle, salinomycin can improve feed conversion efficiency and weight gain.
C. Research and Potential Anti-Cancer Therapy
Experimental studies indicate salinomycin selectively targets cancer stem cells (CSCs) in various cancers, including breast, colorectal, and prostate cancers.
Demonstrated ability to overcome chemotherapy resistance by eliminating CSCs, which are often responsible for tumor relapse.
Investigated as a potential adjunct in cancer treatment, although clinical use remains under research.
Benefits
A. Effective Control of Coccidiosis
Prevents economic losses in poultry farming by reducing mortality and improving flock health.
Enhances feed intake and growth by reducing disease burden.
B. Feed Efficiency and Growth Promotion
Improves feed utilization in ruminants, leading to faster weight gain and better production efficiency.
C. Novel Anti-Cancer Potential
Unique mode of action against cancer stem cells offers promising therapeutic avenues beyond conventional chemotherapy.
Potential to reduce tumor recurrence and metastasis by targeting resistant cancer cell populations.
D. Low Risk of Resistance Development
Ionophore antibiotics like salinomycin exhibit a different mechanism than common antibiotics, limiting cross-resistance.
Conclusion
Salinomycin丨CAS 53003-10-4 is a potent anticoccidial antibiotic widely used in poultry production to control coccidiosis and improve flock performance. Additionally, it enhances feed efficiency in ruminants and holds promising potential as a novel anti-cancer agent targeting resistant cancer stem cells. Its usage requires careful dosing due to toxicity risks in non-target species, particularly horses. When applied responsibly under regulatory frameworks, salinomycin is a valuable tool in animal health and possibly in future cancer therapies.
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