CAS · 55963-78-5
Product Overview
Polyanetholesulfonate is a high-purity nutrient-additives supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Property | Specification |
|---|---|
| Appearance | Tan yellow to off white solid |
| Colour (2% aqueous, 490nm) | 0.10 AU max. |
| pH 1% (30 minutes stirring) | 5.0 - 7.0 |
| Water | 15.0% max. |
| Heavy Metals (Pb) | 0.0001% max. |
| Calcium | 0.10% max. |
| Absorbance (0.02 mg/ml in water) | 0.140 ~ 0.170 |
| Wavelength max. | 283.0 - 285.0 nm |
Applications
1. Clinical Microbiology and Blood Culture Media
Polyanetholesulfonate is most prominently used in blood culture bottles to promote the growth and detection of pathogenic microorganisms.
● Anticoagulant function: Prevents blood clot formation, allowing microbes to remain in suspension for accurate culturing.
● Neutralizes immune components: Binds to complement proteins and some antimicrobial peptides, reducing bactericidal effects and enhancing microbial recovery.
● Enhances detection: Particularly useful for isolating fastidious or slow-growing organisms such as Neisseria, Haemophilus, and Streptococcus.
2. Research in Bacteriology and Antibiotic Testing
In laboratory and pharmaceutical settings, Polyanetholesulfonate丨CAS 55963-78-5 is used to create more physiologically accurate culture conditions when testing bacterial behavior or antibiotic efficacy.
● Improved bacterial viability: Maintains a stable environment that closely resembles in vivo conditions, increasing the reproducibility of results.
● Supports polymicrobial growth: Useful in studying interactions among different microbial species in co-infection models or microbiome research.
3. Anticoagulant in Diagnostic Applications
As a blood anticoagulant, polyanetholesulfonate is sometimes included in diagnostic reagents and test kits to maintain sample integrity during analysis.
● Prevents coagulation: Ensures that cellular and biochemical components remain measurable without interference from clotting.
● Stable during storage: Allows extended testing timelines and minimizes the need for immediate sample processing.
4. Biotechnology and Cell Culture Systems
Although less common, polyanetholesulfonate's polyelectrolyte properties have potential uses in cell culture systems and biosensor platforms, particularly for applications involving surface modification, protein stabilization, or controlled bioactivity.
● Surface coating: Helps in immobilizing biomolecules or cells onto substrates for testing or biosensing.
● Charge balance agent: May be incorporated into formulations to adjust ionic strength and buffering behavior.
Benefits
1. Enhances Microbial Detection Sensitivity
By suppressing natural host defenses (e.g., complement activity, phagocytosis), polyanetholesulfonate increases the recovery rate of viable microorganisms from blood samples, improving diagnostic accuracy.
● Vital for sepsis diagnostics: Rapid and accurate identification of bloodstream infections is critical for timely treatment.
● Broad-spectrum compatibility: Supports growth of both Gram-positive and Gram-negative bacteria, as well as some anaerobes.
2. Stable and Soluble in Aqueous Systems
Its high water solubility makes it easy to incorporate into diagnostic media and reagent solutions.
● No precipitation: Ensures homogeneous distribution and consistent action.
● Compatible with autoclaving: Withstands sterilization without degradation, ensuring safe and sterile application.
3. Non-toxic and Inert to Most Analytical Processes
Polyanetholesulfonate does not interfere with most biochemical assays or analytical procedures, making it suitable for clinical diagnostics and research use.
● Low reactivity: Minimizes background noise in sensitive detection platforms.
● Non-interfering with antibiotics: Allows accurate testing of antimicrobial susceptibility.
4. Dual Action: Anticoagulant and Immunosuppressant
Its dual role in preventing coagulation and neutralizing host defenses enhances its efficiency in blood sample analysis.
● One-step preparation: Reduces the need for multiple additives in culture media.
● Consistent results: Improves test standardization and reproducibility across labs and test systems.
5. Scalable for Commercial Diagnostic Use
Polyanetholesulfonate丨CAS 55963-78-5 is commercially scalable and cost-effective, making it a preferred additive in mass-produced blood culture bottles and diagnostic kits.
● Reliable performance: Proven utility in clinical diagnostics for over several decades.
● Regulatory familiarity: Recognized by various pharmacopeias and diagnostic standard organizations.
Conclusion
Polyanetholesulfonate丨CAS 55963-78-5 is an essential component in microbiological diagnostics, particularly for blood culture systems, where it enhances pathogen recovery, prevents clotting, and neutralizes inhibitory host responses. With its reliable performance, ease of use, and minimal interference in laboratory procedures, it continues to play a crucial role in improving clinical outcomes, research quality, and diagnostic sensitivity across healthcare and life sciences.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.