CAS · 71989-31-6
Product Overview
Fmoc-L-Proline is a high-purity amino-acids supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White powder |
|---|---|
| Purity (HPLC) | 99% min |
| TLC | 98% min |
| Optical Purity | 0.3% D-enantiomer max |
| Specific Rotation (20/D) | -32±2° (C=1 in DMF) |
| Melting Point | 100-118 °C |
| H2O (K.F.) | 3.0% max |
| Clarity of solution | 0.3 g in 2 mL DMF clear solution |
| Loss on drying (50 °C, 2h) | 1.0% max |
| Kaiser test | 0.05% max |
| Element analysis (C, H, N) | 5% max |
| IR spectrum | In accordance with the structure |
| Mass spectrum | In accordance with the structure |
| NMR spectrum | In accordance with the structure |
Applications
Fmoc-L-Proline (CAS 71989-31-6) is a protected amino acid widely used in peptide synthesis and pharmaceutical research. Its primary application is as a building block in solid-phase and solution-phase peptide synthesis, where the Fmoc (9-fluorenylmethoxycarbonyl) group protects the amino group of L-proline during chain assembly. This protection prevents undesired side reactions, ensuring correct peptide sequence formation and structural integrity. Fmoc-L-Proline is particularly valuable in synthesizing cyclic peptides, proline-rich sequences, and bioactive peptides, serving as a versatile intermediate for pharmaceutical, biochemical, and research applications.
Benefits
The benefits of Fmoc-L-Proline stem from its ability to enable efficient, controlled, and high-purity peptide synthesis. The Fmoc group is stable under mildly acidic conditions but can be selectively removed under basic conditions, allowing precise deprotection at specific stages of synthesis. Its incorporation facilitates the production of peptides with complex sequences, including those containing cis- or trans-proline conformations, which are critical for biological activity. Additionally, its compatibility with other protecting groups and reagents ensures flexibility in multi-step peptide syntheses, improving overall yield and purity.
Conclusion
In conclusion, Fmoc-L-Proline is an essential intermediate for peptide synthesis and pharmaceutical research. Its Fmoc protection enables precise, high-quality construction of proline-containing peptides, supporting the development of bioactive molecules and therapeutic agents. By allowing controlled and efficient chemical manipulation, Fmoc-L-Proline plays a vital role in modern peptide chemistry and drug discovery.
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